Sökning: "Cancer Progression"

Visar resultat 16 - 20 av 716 avhandlingar innehållade orden Cancer Progression.

  1. 16. Obesity, Adipocytes and Breast Cancer – Insights from Translational Studies

    Författare :Malin Bergqvist; Bröstcancer - prevention & intervention; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Breast cancer risk; Breast cancer prognosis; Obesity; Adipocyte; Adipokines; CAP; Neutrophil to lymphocyte ratio;

    Sammanfattning : Background: Being overweight is becoming the new normal, and more than half of the adult Swedish population is overweight which poses a risk to public health. Overweight and obese women have both an increased risk and a worse prognosis for breast cancer, compared with women of normal weight. LÄS MER

  3. 17. Utility of novel drug targets for treatment of metastatic cancer

    Författare :Tianyan Wang; Jenny Persson; Thomas Grundström; Maréne Landström; Margareta Wilhelm; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic cancer; castration-resistant prostate cancer; pancreatic ductal adenocarcinoma; target therapy; PIP5K1α; KRAS; molecularly imprinted polymers; Oncology; onkologi; molekylärbiologi; Molecular Biology; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Metastasis is the leading cause of cancer death because of a lack of early diagnosis tools and efficient treatment drugs. The lipid kinase phosphatidylinositol 4-phosphate 5 kinase (PIP5K1α) has been shown to play a vital role in the PI3K/AKT and KRAS signaling pathways. LÄS MER

  4. 18. Anti-Tumor Effects of CysLT2R in Epithelial Cancer

    Författare :Cecilia Magnusson; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; migration; Colon cancer; breast cancer; EGF; interferon;

    Sammanfattning : The pro-inflammatory cysteinyl leukotrienes (cysLTs) are implicated in several pathological disorders, such as asthma and inflammatory diseases. The well-established connection between chronic inflammation and cancer implicates inflammatory mediators in cancer progression. It is therefore of interest to examine the effects of the CysLTs in cancer. LÄS MER

  5. 19. Platelets – Multifaceted players in tumor progression and vascular function

    Författare :Yanyu Zhang; Anna-Karin Olsson; Gertraud Orend; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Tumor; Platelet; HRG; PDGFB; TBK1; NETs; Angiogenesis; EMT; Metastasis; Medicinsk vetenskap; Medical Science; Oncology; Onkologi; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Sammanfattning : Platelets play a crucial role for blood hemostasis, the process that prevents bleeding. In addition, platelets have been demonstrated to promote cancer progression and cancer related complications like metastasis and thrombosis. LÄS MER

  7. 20. CD93 in regulation of vascular function and tumour progression

    Författare :Kalyani Vemuri; Anna Dimberg; Pipsa Saharinen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD93; Tumour angiogenesis; Vascular permeability; Endothelial junctions; Cancer; Glioblastoma; Metastasis;

    Sammanfattning : To achieve successful vascular targeting in cancer, a better understanding of the molecular mechanisms that lead to tumour vascular abnormalities is required.  The transmembrane protein CD93 is highly expressed in the vasculature of several tumours including glioblastoma and has emerged as a potential anti-angiogenic target. LÄS MER