Sökning: "Calcium channel blockers"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Calcium channel blockers.

  1. 1. Calcium regulation and functions of basic Helix-Loop-Helix transcription factors

    Författare :Juha Saarikettu; Thomas Grundström; Dan Holmberg; Mikael Sigvardsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; calcium; calmodulin; calretinin; transcription; bHLH; E-protein; E2-2; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The members of the ubiquitously expressed E-protein subfamily of basic Helix-Loop-Helix (bHLH) transcription factors, E12/E47, SEF2-1 and HEB, have important roles as regulators of gene expression in various differentiation processes, including lymphocyte development and myogenesis. In myogenesis, E-proteins are proposed to function as obligate heterodimer partners for members of the MyoD family of muscle-specific bHLH transcription factors. LÄS MER

  3. 2. On the mechanisms and physiological function of somatodendritic dopamine release in substantia nigra

    Författare :Filip Bergquist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Calcium channels; dopamine release; microdialysis; rotarod; SNARE; striatum; substantia nigra;

    Sammanfattning : Somatodendritic release of neurotransmitters is a neuronal function that is poorly understood in comparison with the more abundant terminal release. This study aimed at characterising somatodendritic dopamine release in substantia nigra in terms of release mechanisms and possible physiological function in motor control. LÄS MER

  4. 3. New insights in parathyroid hormone secretion : with focus on exocytosis and calcium signaling

    Författare :Ming Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The parathyroid is distinguished from other endocrine systems since its primary stimuli inhibit hormone secretion. It is generally considered that extracellular Ca2+ binds to a membrane receptor (calcium sensing receptor, or CaSR), and via second messengers modulate parathyroid hormone (PTH) secretion. LÄS MER

  5. 4. Antiarrhythmic and arrhythmic effects of an Ikr-blocking class III agent. A clinical and electrocardiographic study of almokalant

    Författare :Birgitta Houltz; Göteborgs universitet; []
    Nyckelord :Almokalant; class III antiarrhythmic agent; potassium channel blocker; atrial fibrillation; sinus rhythm; conversion; electrocardiographic; QT interval prolongation; T wave morphology; prediction; torsades de pointes; proarrhythmia; QT dispersion; ventric;

    Sammanfattning : The interest in class III drugs has increased over the last decades as being potent antiarrhythmic agents in their mode of action by prolongation of repolarization and with no effect on conduction. Class I antiarrhythmic agents have proven effective in conversion of atrial fibrillation (AF), but may cause serious proarrhythmia. LÄS MER

  7. 5. Drug use in the elderly : risk or protection? Findings from the Kungsholmen project

    Författare :Christel Cornelius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug use; elderly; dementia; Alzheimer s disease; aspirin; NSAIDs; glucocorticoids; calcium channel blockers; apolipoprotein E; population-based study.;

    Sammanfattning : This thesis deals with different aspects of drug use in a population-based study with participants 75 years and older. The study was performed within the Kungsholmen Project in Stockholm, Sweden, using data from the baseline survey (1987-89), and the first (1991-93) and second (1994-96) followups In the first two papers we used cross-sectional data (n=1810) to describe tile drug Ilse pattern ill this population (I), and to examine the association between self-reported symptoms and drug use (II). LÄS MER