Sökning: "Calcineurin"
Visar resultat 26 - 30 av 34 avhandlingar innehållade ordet Calcineurin.
26. Regulation of mast cell survival and apoptosis
Sammanfattning : Mature mast cells reside in the tissue as heavily granulated cells possessing a regulatory function in innate and adaptive immunity against pathogens, but also detrimentally in atopic, as well as, chronic inflammation-associated diseases such as allergic reactions and autoimmunity. Upon stimulation, mast cells release a vast variety of mediators that recruit and stimulate other immune cells, induce vasodilation and angiogenesis, and process and degrade proteins. LÄS MER
27. Statin-induced cellular effects mediated by the P2X7 receptor
Sammanfattning : Cholesterol-lowering statins have been shown to inhibit growth of different cancer cells both in vitro and in vivo. Epidemiological studies also indicate a chemopreventive effect of statins. We have investigated the effect of statins on Akt/protein kinase B signaling and their sensitizing effect of cytostatic drugs. LÄS MER
28. The reactive stroma in pancreatic diseases
Sammanfattning : Stroma, or activated connective tissue, is a key component in both pancreatitis and pancreatic tumors. Acute pancreatitis (AP) is an inflammation of the pancreas which ranges from mild and local to systemic with severe complications and high mortality. LÄS MER
29. Regulation of T-cell proliferation and B-CLL apoptosis by CD6 and FAS/FASL
Sammanfattning : T-cell activation involves the interaction between the T-cell receptor (TCR) and the peptide/MHC complex presented on an antigen-presenting cell. However, this is not sufficient for the full development of T cell responses and co-stimulatory signals from accessory molecules are required. LÄS MER
30. Effects of imidazoline compounds on intracellular CA2+ and apoptosis
Sammanfattning : Cytoplasmic free Ca2+ concentration ([Ca2+]i) plays a pivotal role in the regulation of insulin release from the pancreatic beta-cell. [Ca2+]i is also important in the control of apoptosis. LÄS MER