Sökning: "Calcineurin"

Visar resultat 26 - 30 av 34 avhandlingar innehållade ordet Calcineurin.

  1. 26. Regulation of mast cell survival and apoptosis

    Författare :Mats Karlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mature mast cells reside in the tissue as heavily granulated cells possessing a regulatory function in innate and adaptive immunity against pathogens, but also detrimentally in atopic, as well as, chronic inflammation-associated diseases such as allergic reactions and autoimmunity. Upon stimulation, mast cells release a vast variety of mediators that recruit and stimulate other immune cells, induce vasodilation and angiogenesis, and process and degrade proteins. LÄS MER

  3. 27. Statin-induced cellular effects mediated by the P2X7 receptor

    Författare :Oras Mistafa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cholesterol-lowering statins have been shown to inhibit growth of different cancer cells both in vitro and in vivo. Epidemiological studies also indicate a chemopreventive effect of statins. We have investigated the effect of statins on Akt/protein kinase B signaling and their sensitizing effect of cytostatic drugs. LÄS MER

  4. 28. The reactive stroma in pancreatic diseases

    Författare :Jessica Norberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Stroma, or activated connective tissue, is a key component in both pancreatitis and pancreatic tumors. Acute pancreatitis (AP) is an inflammation of the pancreas which ranges from mild and local to systemic with severe complications and high mortality. LÄS MER

  5. 29. Regulation of T-cell proliferation and B-CLL apoptosis by CD6 and FAS/FASL

    Författare :Lydia Maria Osorio Fernández; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T-cell activation; CD6; B-CLL; apoptosis; Fas; FasL;

    Sammanfattning : T-cell activation involves the interaction between the T-cell receptor (TCR) and the peptide/MHC complex presented on an antigen-presenting cell. However, this is not sufficient for the full development of T cell responses and co-stimulatory signals from accessory molecules are required. LÄS MER

  7. 30. Effects of imidazoline compounds on intracellular CA2+ and apoptosis

    Författare :Ioulia Appelskog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :imidazolines; imidazoline site; sulfonylurea; glucose; interleukin-1beta; insulin secretion; glucagon; somatostatin; pancreatic islets; pancreatic P-cells; HIT-T15 cells; apoptosis; cytoplasmic free Ca2 concentration;

    Sammanfattning : Cytoplasmic free Ca2+ concentration ([Ca2+]i) plays a pivotal role in the regulation of insulin release from the pancreatic beta-cell. [Ca2+]i is also important in the control of apoptosis. LÄS MER