Sökning: "Calcineurin"

Visar resultat 21 - 25 av 34 avhandlingar innehållade ordet Calcineurin.

  1. 21. Effects of immunosuppressive drugs on human adipose tissue metabolism

    Författare :Maria J Pereira; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake; lipolysis; lipogenesis;

    Sammanfattning : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. LÄS MER

  3. 22. Mechanisms of apoptosis in secretory and neuronal cells : role of oxidative stress and calcium overload

    Författare :Maria Ankarcrona; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Apoptosis is a widespread physiological mechanism to regulate tissue homeostasis both during development and in adult organs. However, the cell deletion program can be inappropriately activated or suppressed under pathological conditions. LÄS MER

  4. 23. Effects and mechanisms of actions of cyclosporin, FK506 and 15-deoxyspergualin

    Författare :Anette Johansson Borg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cyclosporin; FK506; 15-deoxyspergualin; immunosuppressive effects; transplantation;

    Sammanfattning : Immunosuppressive drugs can be used to deal with unwanted or inappropriate immune reactions, such as the rejection of a transplanted organ. However, treatment with these drugs are often associated with serious adverse effects, and therefore less toxic immunosuppressants are desired. LÄS MER

  5. 24. Renal injury in liver transplantation clinical and mechanistic studies

    Författare :Åsa Norén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver transplantation; Renal injury; Ischemia reperfusion injury;

    Sammanfattning : ABSTRACT Background: Renal injury in liver transplantation (LT) is common and presents both as early and late insufficiency. These conditions are interconnected and have substantial impact on the long-term outcome. LÄS MER

  7. 25. OVULATION: Intra-ovarian mechanisms

    Författare :Farnosh Sørensen Zakerkish; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ovulation; Human;

    Sammanfattning : Background: Ovulation is the central biological process involved in the menstrual cycle of women. Specifically, ovulation involves the tissue remodelling of the preovulatory follicle to achieve the rupture of the exterior follicle wall with the extrusion of the oocyte. LÄS MER