Sökning: "Calcineurin"
Visar resultat 16 - 20 av 34 avhandlingar innehållade ordet Calcineurin.
16. Conjugated polyelectrolytes : conformation sensitive optical probes for the recording of biological processes
Sammanfattning : The physical properties of conjugated polymers can be utilized for a wide range of biosensors. For instance, the conformational flexibility fouud in conjugated polyelectrolytes, allows direct connection between the geometry of chains and the resulting electronic structure and optical processes, since the extension of the π-conjugated system is distorted by conformational changes of the polyelectrolyte backbone. LÄS MER
17. Mechanism of action of autosomal recessive juvenile parkinsonism gene mutations
Sammanfattning : Parkinson Disease (PD) is the most common neurodegenerative movement disorder. Although PD is a largely sporadic disease, several genes has been linked to familial forms of PD. This thesis focuses on the mechanism of function of the Autosomal Recessively Juvenile Parkinsonism (AR-JP) associated genes parkin, PTEN induced kinase 1 (PINK1) and DJ-1. LÄS MER
18. Akt signaling and coordinated changes in the distribution and expression of Akt-regulating phosphatases
Sammanfattning : Cancer is one of the major causes of death worldwide. The PI3K/Akt signaling pathway is up-regulated in a variety of human cancers. Akt is an important signaling molecule in cellular survival pathways. Activated Akt (pAkt) is able to induce protein synthesis pathways, and is therefore a key protein involved in growth and prevention of apoptosis. LÄS MER
19. NFAT signaling in chronic and acute inflammation - A novel target for the treatment of diabetic vascular complications and acute pancreatitis?
Sammanfattning : Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. LÄS MER
20. Heterobasidion root rot : genetic mapping of virulence and evolutionary history
Sammanfattning : Heterobasidion annosum (Fr.) Bref. sensu lato (s.l. LÄS MER