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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Signal transduction via ion fluxes : a cell imaging study with emphasis on calcium oscillations

    Författare :Per Uhlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Calcium; Ca2 signalling; Ca2 oscillation; InsP3; InsP3 receptor; Na; K-ATPase; ouabain; physical interaction; FRET; spectral analysis; confocal microscopy;

    Sammanfattning : Signal transduction via ion fluxes is of vital importance for all mammalian cells. Cells can exploit ion regulatory mechanisms to generate and transmit intracellular signals. Improvements in digital microscopic imaging technology have made it possible to explore micro-environments and complex intracellular machineries. LÄS MER

  3. 2. Dopaminergic and serotonergic modulation of cellular and locomotor network properties in the lamprey spinal cord

    Författare :Martin Wikström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :5-hydroxytryptamine; Dopamine; Calcium channels; Calcium-dependent potassium channels; Afterhyperpolarization; Membrane potential oscillation; Synaptic transmission; Modulation; Central pattern generator; Locomotion; Spinal cord; Lamprey;

    Sammanfattning : Motor activity is the basis for all behavior. It is therefore important to study the processes generating movement such as the neuronal networks in the spinal cord that generates and controls locomotion. The lamprey is used as a model system for the study of locomotion. LÄS MER

  4. 3. Effects of bacterial toxins on calcium homeostasis in renal inflammation

    Författare :Tomas Söderblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Calcium (Ca2+) is a highly versatile ion used for intra- and inter-cellular signalling in eukaryotic cells, and numerous cellular events are regulated by alteration of the intracellular Ca2+ concentration. We hypothesized that bacterial virulence factors may alter the Ca 2+ homeostasis in epithelial cells such that the innate immune response is affected. LÄS MER

  5. 4. Cellular mechanisms of interaction between uropathogenic Escherichia coli and renal epithelial cells

    Författare :Åsa Laestadius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Urinary tract infections will often, particularly in children, lead to renal scar formation or hypoplastic small kidneys post-infectiously. The most common causative agent is uropathogenic Escherichia coli (E. coli). LÄS MER

  7. 5. The role of CART in islet function

    Författare :Mia Abels; Neuroendokrin cellbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocaine- and amphetamine-regulated transcript; CART; Diabetes; T2D; Human islets; Glucagon; Insulin; Adipocyte;

    Sammanfattning : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. LÄS MER