Sökning: "CYP2EI"

Hittade 2 avhandlingar innehållade ordet CYP2EI.

  1. 1. Genetic polymorphism of xenobiotic metabolising enzymes : implications for interindividual and interethnic differences in drug metabolism and cancer susceptibility

    Författare :Irene Persson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lung cancer; drug metabolism; genetic polymorphism; cytochrome P450; CYPIAI; CYP2EI; CYP2D6; interethnic differences.;

    Sammanfattning : Genetic factors are of importance for interindividual and interethnic differences in drug response and cancer susceptibility. In the present investigation the role of genetic polymorphism in the cytochromes P450 CYPIAI, CYP2C19, CYP2D6, CYP2EI as well as in glutathione S-transferase Ml (GSTMI) and microsomal epoxide hydrolase (mEH) for differences in drug response and cancer susceptibility has been investigated in various ethnic populations. LÄS MER

  3. 2. Toxicological and endocrinolgical aspects of cytochrome P450 in breast and lung

    Författare :Heike Hellmold; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cytochrome P450; breast; lung; metabolism;

    Sammanfattning : Cytochrome P450 (CYP) enzymes have well characterized functions in disposition and pharmacokinetics of xenobiotics as well as in biosynthesis and/or metabolism of endogenous compounds, such as steroid hormones, bile acids, arachidonic acid and its derivatives. Cytochrome P450 mediated metabolic activation is known to be a prerequisite for the cytotoxic and mutagenic activity of many environmental toxins and procarcinogens. LÄS MER