Sökning: "CYP2CI9"

Hittade 2 avhandlingar innehållade ordet CYP2CI9.

1. 1. Enantioselective drug metabolism catalysed by the polymorphic CYP2D6 and CYP2C19 : a methodological investigation focused on mianserin, mephenytoin and omeprazole

   Författare :Gunnel Tybring; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Drug metabolism; CYP2D6; CYP2CI9; mianserin; mephenytoin; omeprazole; enantiomers; chiral analysis;

   Sammanfattning : The aim of this thesis was to develop enantioselective analytical methods and apply them to studies of oxidative metabolism of chiral drugs catalysed by the polymorphic cytochrome P450 CYP2D6 and CYP2C 19 enzymes. The work has been focused on mianserin, mephenytoin and omeprazole. LÄS MER

3. 2. Genetic polymorphism of xenobiotic metabolising enzymes : implications for interindividual and interethnic differences in drug metabolism and cancer susceptibility

   Författare :Irene Persson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Lung cancer; drug metabolism; genetic polymorphism; cytochrome P450; CYPIAI; CYP2EI; CYP2D6; interethnic differences.;

   Sammanfattning : Genetic factors are of importance for interindividual and interethnic differences in drug response and cancer susceptibility. In the present investigation the role of genetic polymorphism in the cytochromes P450 CYPIAI, CYP2C19, CYP2D6, CYP2EI as well as in glutathione S-transferase Ml (GSTMI) and microsomal epoxide hydrolase (mEH) for differences in drug response and cancer susceptibility has been investigated in various ethnic populations. LÄS MER