Sökning: "CYP1B1"

Visar resultat 6 - 10 av 15 avhandlingar innehållade ordet CYP1B1.

  1. 6. Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor

    Författare :Roman A McLellan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The vast number of human xenobiotic-metabolising enzymes display interindividual variability that can alter the disposition of any compound metabolised by these enzymes, including environmental chemicals and many clinically used drugs. Both genetic and non-genetic factors affect the levels and activities of these enzymes. LÄS MER

  3. 7. Genetic susceptibility to breast and endometrial cancer

    Författare :Sara Wedrén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hormones are central in the carcinogenic process in the breast and in the uterine epithelium. Individual genetically determined variation in the response to hormonal influence may alter susceptibility to breast and endometrial cancers. Many small studies of this hypothesis have generated inconclusive results. LÄS MER

  4. 8. Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer

    Författare :Torbjörn Söderström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genes that are responsible for variations in drug and hormonal responses are sometimes also associated with the pathophysiology of diseases. Understanding the aetiology of a disease is often essential for the design of effective drugs. Androgens are implicated in the development of prostate cancer and benign prostate hyperplasia (BPI]). LÄS MER

  5. 9. Xenobiotic-metabolizing enzymes and enzymes involved in the metabolism of reactive oxygen species in the porcine ovary : subcellular distributions and levels of expression during follicular maturation and in the non-pregnant and pregnant corpus luteum

    Författare :Maria Eliasson; Thomas Friedberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Sammanfattning : The polycyclic aromatic hydrocarbon (PAH) 7,12-dimethylbenz(a)anthracene (DMBA) is metabolized by both porcine ovarian microsomes and mitochondria, with the highest activity being seen in the corpus luteum. Microsomal DMBA monooxygenase activity is inhibited by inhibitors of the CYP450 system and by 17-bestradiol, thus indicating involvement of CYP1B1. LÄS MER

  7. 10. Adrenal Bioactivation and Toxicity of 3-MeSO2-DDE, o,p´-DDD and DMBA Investigated in Tissue Slice Culture

    Författare :Örjan Lindhe; Jan Alexander; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; adrenal cortex; 3-MeSO2-DDE; o; p´-DDD; DMBA; bioactivation; binding; toxic; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Ecotoxicology; ekotoxikologi;

    Sammanfattning : I developed a precision-cut adrenal slice culture procedure to investigate cytochrome P450 (CYP) catalysed irreversible binding and adrenocorticolytic effects in human, rodent, and fish adrenal tissue, ex vivo. Autoradiography and radioluminography of exposed tissue slices showed that the potent adrenal toxicant 3-methylsulphonyl-2,2´-bis(4-chlorophenyl)-1,1´-dichloroethene (MeSO2-DDE) causes a selective metabolite binding in zona fasciculata (ZF), which is diminished by the CYP11B1 inhibitor metyrapone. LÄS MER