Sökning: "CYP1A inducers"

Hittade 5 avhandlingar innehållade orden CYP1A inducers.

1. 1. Evaluation of Biomarker Responses in Fish : with Special Emphasis on Gill EROD Activity

   Författare :Carin Andersson; Jan Örberg; Björn Brunström; Lars Förlin; Uppsala universitet; []
   Nyckelord :Biology; three-spined stickleback; biomarker; EROD; ethynylestradiol; gill; vitellogenin; spiggin; CYP1A inducers; humic substances; sperm quality; biomonitoring; Biologi;

   Sammanfattning : Many chemicals present in the aquatic environment can interfere with physiological functions in fish. Exposure to chemicals can be revealed by the use of biomarkers. Induction of 7-ethoxyresorufin O-deethylase (EROD) activity is a commonly used biomarker for exposure to CYP1A inducers such as dioxins and polyaromatic hyrdrocarbons. LÄS MER

3. 2. Gill EROD Activity in Fish : A Biomarker for Waterborne Ah-receptor Agonists

   Författare :Alexandra Abrahamson; Ingvar Brandt; Björn Brunström; Janneche Utne Skaare; Uppsala universitet; []
   Nyckelord :Biology; biomarker; fish; gill; CYP1A; EROD; environmental monitoring; induction; inhibition; PAH; PCB; produced water; Biologi;

   Sammanfattning : Induction of the cytochrome P450(CYP)1A protein and the connected increase in 7-ethoxyresorufin O-deethylase (EROD) activity are common biomarkers in fish. Enhanced activity of this protein signals exposure to Ah-receptor agonists such as chlorinated dioxins, co-planar polychlorinated biphenyls (PCBs) and certain polycyclic aromatic hydrocarbons (PAHs). LÄS MER

4. 3. A Gill Filament EROD Assay : Development and Application in Environmental Monitoring

   Författare :Maria Jönsson; Ingvar Brandt; Björn Brunström; Kristian Ingebrigtsen; Håkan Olsén; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; aquatic; benzo[a]pyrene; biomarker; CYP1A; environmental monitoring; EROD; fish; gill; indigo; PCB; Biologi; Biology; Biologi;

   Sammanfattning : A gill filament-based assay for the cytochrome P450 1A (CYP1A)-catalysed activity ethoxyresorufin O-deethylase (EROD) was developed in rainbow trout (Oncorhynchus mykiss) and applied to Atlantic salmon (Salmo salar), Arctic charr (Salvelinus alpinus), Atlantic cod (Gadus morhua), saithe (Pollachius virens), and spotted wolffish (Anarhichas minor). Exposure to waterborne β-naphthoflavone (βNF; 10-6 M) induced branchial EROD activity in all species but the spotted wolffish. LÄS MER

5. 4. Bioactivation and binding of polycyclic aromatic hydrocarbons in blood vessel endothelia

   Författare :Lizette Granberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Polycyclic aromatic hydrocarbon; PAH; endothelial cells; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Ecotoxicology; ekotoxikologi;

   Sammanfattning : Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants formed by incomplete combustion of organic materials such as fossil fuels and wood. Experimental and epidemiological studies indicate that PAHs may be involved in the development of cardiovascular disease. LÄS MER

7. 5. Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo

   Författare :Kajsa P Kanebratt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The cytochrome P450 (P450) enzymes comprise the most important enzyme system with regard to phase I metabolism of drugs. Induction of P450s can result in decreased plasma concentrations of the drug itself or a coadminstered drug, followed by lack of effect. LÄS MER