Sökning: "CYP"

Visar resultat 21 - 25 av 88 avhandlingar innehållade ordet CYP.

1. 21. Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism

   Författare :Magnus Christensen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Drug metabolism; phenotype; CYP1A2; caffeine; melatonin; fluvoxamine; omeprazole; losartan; debrisoquine; quinine; genotype; single nucleotide polymorphism;

   Sammanfattning : Assessment of the cytochrome (CYP) P450 enzyme activity or phenotyping is a method to characterise the real activity of an enzyme by the use of a marker probe drug. The information of the phenotype is of clinical relevance because it reflects the combined effects of genetic, environmental e.g. LÄS MER

3. 22. The in-vitro and in-vivo metabolism of the oral anticoagulant phenprocoumon as influenced by genetic polymorphisms of cytochrome P4502C9

   Författare :Mike Ufer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Drug metabolism; cytochrome P450; genetic polymorphism; genotyping; CYP2C9; phenprocoumon; warfarin; acenocoumarol; oral anticoagulants;

   Sammanfattning : Oral anticoagulants are widely used for the prevention of thromboembolic disorders. Warfarin (WA) is most commonly used world-wide, while phenprocoumon (PPC) is the first-line anticoagulant in some European countries including Germany. Each anticoagulant exists in two different enantiomeric forms and is administered orally as a racemate. LÄS MER

4. 23. Optimization of cyclophosphamide therapy based on pharmacogenetics

   Författare :Parvaneh Afsharian; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cyclophosphamide; Pharmacogenetics; Pharmacokinetics; Cytochrome P450; CYP2136; Ciprofloxacin;

   Sammanfattning : Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by a 4-hydroxylation reaction catalyzed by cytochrome P450 (CYP) enzymes. LÄS MER

5. 24. Interactions between cytochrome P450 and estrogenic compounds in fish

   Författare :Linda Hasselberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; CYP1A; CYP3A; glutathione; alkylphenols; ethynylestradiol; ketoconazole; vitellogenin; Atlantic cod; rainbow trout; fish;

   Sammanfattning : DISSERTATION ABSTRACT Hasselberg, Linda. Interactions between cytochrome P450 and estrogenic compounds in fish. Department of Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden Contamination by various pollutions is an environmental concern. LÄS MER

7. 25. Adrenal Bioactivation and Toxicity of 3-MeSO2-DDE, o,p´-DDD and DMBA Investigated in Tissue Slice Culture

   Författare :Örjan Lindhe; Jan Alexander; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; adrenal cortex; 3-MeSO2-DDE; o; p´-DDD; DMBA; bioactivation; binding; toxic; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Ecotoxicology; ekotoxikologi;

   Sammanfattning : I developed a precision-cut adrenal slice culture procedure to investigate cytochrome P450 (CYP) catalysed irreversible binding and adrenocorticolytic effects in human, rodent, and fish adrenal tissue, ex vivo. Autoradiography and radioluminography of exposed tissue slices showed that the potent adrenal toxicant 3-methylsulphonyl-2,2´-bis(4-chlorophenyl)-1,1´-dichloroethene (MeSO2-DDE) causes a selective metabolite binding in zona fasciculata (ZF), which is diminished by the CYP11B1 inhibitor metyrapone. LÄS MER