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Visar resultat 1 - 5 av 81 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Activation of murine cytotoxic cells with interelukin-2 and the bacterial superantigen staphylococcal entertoxin A

    Författare :Hans Belfrage; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; Immunology; cytokine; tolerance; LAK; NK; serologi; CTL; Staphylococcal enterotoxin A; SEA; Interleukin-2; murine; deletion; anergy;

    Sammanfattning : Natural killer (NK) cells and T lymphocytes are the major effector cells that can recognize and kill tumor cells. NK cells have a constitutive cytotoxic activity and kill a wide spectrum of tumor cells while T cells recognize specific tumor antigens and need to be activated through their TCR to differentiate into cytotoxic T lymphocyte (CTL) killers or T helper cells. LÄS MER

  3. 2. Forestry machine and soil interaction for sustainable forestry

    Författare :Abdurasul Pirnazarov; Ulf Sellgren; Kjell Andersson; Sally Shoop; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; CTL-logging; forestry machine; forwarder; multi-body simulations; roots; terramechanics; wheel-soil interaction; WES model; Machine Design; Maskinkonstruktion;

    Sammanfattning : More than 50 percent of the land area of the Nordic countries Finland, Norway, and Sweden are covered by dense forests and they are among the most important producers of forest products in the world. Forestry in these countries is based on sustainable management principles – reforestation follows harvesting. LÄS MER

  4. 3. T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses

    Författare :Per Grufman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CTL; Dendritic cells; Immunodominance; T-cell competition; IL- 12;

    Sammanfattning : Immunodominance is a process in which the immune response focuses on one or a few of all potential epitopes that exists within an antigen. The mechanisms for immunodominance have not yet been determined. LÄS MER

  5. 4. T-cell mediated control of Epstein-Barr virus infection : viral mechanisms of immune escape

    Författare :Jelena Vladmirovna Levitskaya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Epstein-Barr virus; Cytotoxic T lymphocyte; CTL epitope; viral immunescape;

    Sammanfattning : Mechanisms regulating the immunogenicity of Epstein-Barr Virus (EBV)-encoded CTL peptide epitopes and their contribution to the escape of virus infected cells from CTL-mediated immunosurveillance were the subject of these studies. It was demonstrated that two HLA A11-restricted CTL epitopes of EBV nuclear antigen (EBNA)-4 (designated IVT and AVF) possessed different immunogenicity that appeared to be due to a rapid surface turnover of All molecules containing the AVF peptide. LÄS MER

  7. 5. Allogeneic stem cell transplantation in children : identification and prevention of complications : adoptive transfer of EBV-immunity

    Författare :Åsa Gustafsson Jernberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Children; CTL; EBV; Graft-versus-leukaemia; Stemcell transplantation; unrelated;

    Sammanfattning : Allogeneic stem cell transplantation (SCT) can cure leukaemia, aplastic anaemia, and some inborn errors of metabolism and immunodeficiencies in children. As only 113 of patients who need SCT have an HLA-identical sibling, the use of alternative donors has increased, to over 50% of all paediatric SCTs at our centre. LÄS MER