Sökning: "CSF monoamine metabolites"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden CSF monoamine metabolites.

  1. 1. Molecular genetic studies on cerebrospinal fluid monoamine metabolites in psychotic patients and healthy individuals

    Författare :Dimitrios Andreou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cerebrospinal fluid CSF ;

    Sammanfattning : Dopamine, serotonin and noradrenaline are the major monoamines in the human central nervous system (CNS) and following their basic pathways they are degraded to their major metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), respectively. The cerebrospinal fluid (CSF) concentrations of the three monoamine metabolites (MM) are considered to reflect the monoamine turnover rates in the CNS, are under genetic influence and have been associated with schizophrenia. LÄS MER

  3. 2. Season of birth in suicidology : neurobiological and epidemiological studies

    Författare :Jayanti Chotai; Hans Ågren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; season of birth; CSF monoamine metabolites; suicide method; borderline;

    Sammanfattning : Background: Several neuropsychiatrie disorders have shown season of birth associations. Low cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-HIAA and the dopamine metabolite HVA have been associated with suicidal behaviour, impulsivity, and aggression. LÄS MER

  4. 3. Neuropsychiatric background factors to violent crime

    Författare :Henrik Söderström; Göteborgs universitet; []
    Nyckelord :forensic psychiatry; AD HD; autism; conduct disorder; SPECT; HVA; 5-HIAA; CSF; PCL-R; aggression; violence; psychosis; mood disorder; abuse; and anxiety;

    Sammanfattning : Introduction and aims. Mental disorders among perpetrators of violent and sexual crimes differ from those in the general population in prevalence, course, and patterns of comorbidity. LÄS MER

  5. 4. Genetic aspects on schizophrenia and cerebrospinal fluid monoamine metabolites : focus on association studies with candidate genes

    Författare :Erik Jönsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :association study; schizophrenia; DNA polymorphisms; dopamine receptors DRD2; DRD3; DRD4 ; tyrosine hydroxylase; tryptophan hydroxylase; catechol-O-methyltransferase; neurotrophin-3; ciliary neurotrophic factor; healthy subjects; cerebrospinal fluid;

    Sammanfattning : Schizophrenia is a syndrome with psychotic symptoms. The pathogenesis of schizophrenia most likely reflects brain abnormalities and heritable components are present. The principal objective of the present thesis was to investigate some possible genetic influences in the genesis or pathophysiology of schizophrenia. LÄS MER

  7. 5. Disorders of the cerebral white matter in children

    Författare :Ragnhildur Kristjánsdóttir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leukoencephalopathy - children - neurological impairments - magnetic resonance imaging - ophthalmology - visual evoked potentials - cerebrospinal fluid - sulfatide - glial fibrillary acidic protein - gangliosides - neurofilament - tau protein - monoamine metabolites;

    Sammanfattning : The aims of this thesis were to describe the clinical spectrum in a large group of children characterised as having an abnormal magnetic resonance imaging (MRI) signal from cerebral white matter (WM) and to study the radiological, clinical and ophthalmological features in that subgroup where aetiology was unknown. We also wanted to look at biochemical markers in the cerebrospinal fluid (CSF) to elucidate pathological processes which were responsible for the WM abnormalities. LÄS MER