Sökning: "CRK CRKL ABL BCR acute lymphoid leukemia chronic myeloid leukemia Philadelphia chromosome Molecular"

Hittade 1 avhandling innehållade orden CRK CRKL ABL BCR acute lymphoid leukemia chronic myeloid leukemia Philadelphia chromosome Molecular.

1. 1. Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes

   Författare :Thoas Fioretos; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CRKL; CRK; ABL; BCR; acute lymphoid leukemia; chronic myeloid leukemia; Philadelphia chromosome; Molecular Genetics; Cytogenetics; IFN-alfa; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

   Sammanfattning : In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the first study, children with Ph-positive chronic myeloid leukemia (CML) were found to have essentially the same breakpoint locations in BCR as adults, a pattern which differs from the one seen in Ph-positive acute lymphoid leukemia (ALL). LÄS MER