Sökning: "CREB"
Visar resultat 21 - 25 av 43 avhandlingar innehållade ordet CREB.
21. Skeletal muscle PGC-1α1 and KAT enzymes at the intersection between depression and metabolic disease
Sammanfattning : Depression and metabolic diseases are leading causes of disability and major contributors to socioeconomic burden worldwide. Physical activity exerts many beneficial effects that confer direct health improvement in individuals suffering from these disorders. LÄS MER
22. Targeting chronic lymphocytic leukemia cells using anti-ROR1 monoclonal antibodies and small molecules inhibitors
Sammanfattning : Chronic lymphocytic leukemia (CLL) is characterized by accumulation of malignant B cells in blood, bone marrow, spleen and lymph nodes. It is the most common leukemia in the Western world. Major progress has been made in recent years to prolong the survival and improve the well-being of the patients. LÄS MER
23. Signalling and activation of TLR4 by Gram-negative bacteria in epithelial cells
Sammanfattning : Lipopolysaccharide (LPS) is a well-characterized pathogen-associated molecule found primarily as a constituent of the outer membrane of Gram-negative bacteria. LPS is known to act on different cell types in a pleiotropic manner. LÄS MER
24. Calcium signaling in development and disease
Sammanfattning : The calcium ion (Ca2+) is a highly versatile signaling messenger involved in a diverse range of physiological processes such as gene transcription/expression, proliferation, differentiation and cell death. Intracellular Ca2+ signals are generated through a 10 000 – 20 000 fold gradient across the cell membrane and via release from the external milieu and/or internal Ca2+ stores. LÄS MER
25. Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function
Sammanfattning : Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). LÄS MER