Sökning: "CPP"

Visar resultat 6 - 10 av 66 avhandlingar innehållade ordet CPP.

1. 6. The cerebral circulation in preeclampsia : abnormalities in autoregulation and perfusion

   Författare :Michael A Belfort; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :preeclampsia; eclampsia; autoregulation; cerebral perfusion pressure; Doppler; central retinal artery; ophthalmic artery; middle cerebral artery; magnesium sulfate; nimodipine; headache; scotomata;

   Sammanfattning : Background: Eclampsia continues to be a major cause of maternal death. Abnormal cerebral blood flow and autoregulation may play an important role in the causation. Doppler ultrasound now allows assessment of the pathophysiology of preeclampsia, and the mechanisms of action of drugs used to treat it. LÄS MER

3. 7. Cell-penetrating peptides as delivery vectors for oligonucleotides and proteins : Studies on applications and toxicity

   Författare :Peter Järver; Ülo Langel; Gilles Divita; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Cell-penetrating peptides (CPPs) have for a little bit more than a decade been employed as delivery vectors for a wide range of cargoes, ranging from gold particles to entire plasmids. Although CPP are well studied and utilized in numerous publications, our knowledge about CPP mediated transport is still poor. LÄS MER

4. 8. Neurointensive Care of Children with Severe Traumatic Brain Injury : Studies of barbiturate coma treatment, intracranial compliance, pressure autoregulation and optimal cerebral perfusion pressure

   Författare :Fartein Velle; Per Enblad; Shruti Agrawal; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Children; Refractory intracranial hypertension; Barbiturate coma; Intracranial compensatory reserve; autoregulation; cerebral microdialysis.; Neurokirurgi; Neurosurgery;

   Sammanfattning : Traumatic brain injury (TBI) is among the most common causes of death and acquired disability during childhood. Management guidelines for pediatric patients are usually extrapolated from adults. Specific pediatric studies are warranted to improve the TBI management in children. LÄS MER

5. 9. Pressure autoregulation of cerebral blood flow in traumatic brain injury and aneurysmal subarachnoid hemorrhage

   Författare :Ulf Johnson; Per Enblad; Lars-Owe Koskinen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; autoregulation; traumatic brain injury; subarachnoid hemorrhage; Neurosurgery; Neurokirurgi;

   Sammanfattning : The ability of the brain to keep a stable and adequate cerebral blood flow (CBF) independently of fluctuations in systemic blood pressure is referred to as cerebral pressure autoregulation (CPA). When the brain is injured by trauma or hemorrhage, this ability may be impaired, leaving the brain vulnerable to events of high or low blood pressure. LÄS MER

7. 10. Cell-penetrating peptides : an uptake mechanism & a new endosomolytic peptide

   Författare :Henrik Helmfors; Ülo Langel; Andreas Barth; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Peptide-based drugs have slowly begun migrating from laboratories into pharmacies and now there are several on the market. However, currently only one gene based therapy that is relies on a viral delivery vector has been approved. LÄS MER