Sökning: "COX2"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet COX2.

  1. 1. Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Tereza Planck; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; association study; Graves’ disease; Graves’ ophthalmopathy; immediate early genes; inflammation; adipogenesis; thyrostimulin; BTG2; CYR61; COX2; ZFP36; gene expression; SCD; SNP;

    Sammanfattning : Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. LÄS MER

  2. 2. Telomerase reverse transcriptase (TERT) : promoter mutation and novel function in human cancer

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Författare :Tiantian Liu; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase, an RNAdependent DNA polymerase responsible for telomere elongation. TERT is transcriptionally repressed in most normal human somatic cells with limited life-span, which contributes to telomerase silence. LÄS MER

  3. 3. Fever : Role of brain endothelial prostaglandins

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Daniel Björk Wilhelms; David Engblom; Kazuhiro Nakamura; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Fever and loss of appetite are two of the most fundamental manifestations of disease. These disease symptoms, which lead to deviations from normal body temperature and food intake patterns, are seen in a vast array of infectious and inflammatory conditions. LÄS MER

  4. 4. Telomerase in hematological and other malignancies : therapeutic implications

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Författare :Bingnan Li; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The Telomere is a nucleoprotein complex consisting of TTAGGG repeated sequences covered by specialized binding proteins termed shelterins masking the end of linear chromosomes and thereby protecting the end of the chromosome from genomic instability. Telomeres become progressively shortened during cellular replication and acts as a mitotic clock to confer a limited lifespan to normal cells. LÄS MER

  5. 5. WNT signaling in microglia : WNTs as novel regulators of microglia

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Physiology and Pharmacology

    Författare :Carina Halleskog; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Microglia, the immunocompetent cells of the central nervous system (CNS) and the brain’s own macrophages are the most motile cells in the CNS and those with highest plasticity, as they rapidly move their projections to actively screen their environment for any type of injury. Upon cell damage or infection, microglia respond quickly: they proliferate, change morphology from ramified to amoeboid state to migrate or invade towards the injury, secrete many types of cytokines and chemokines to communicate with other inflammatory cells, and phagocytose cell debris. LÄS MER