Sökning: "CONFORMATIONAL-CHANGES"

Visar resultat 1 - 5 av 149 avhandlingar innehållade ordet CONFORMATIONAL-CHANGES.

  1. 1. Conformational Changes during Potassium-Channel Gating

    Författare :Jakob Renhorn; Fredrik Elinder; David Engblom; Stephan Pless; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ion-channel; electrophysiology; neuron; Jonkanal; neurologi; elektrofysiologi; neuron; aktionspotential;

    Sammanfattning : Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. LÄS MER

  3. 2. Folding and interaction studies of subunits in protein complexes

    Författare :Ximena Aguilar; Stefan Björklund; Alexis Verger; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Macromolecular crowding; cpn10; Mediator; Med25; Dreb2a; VP16; conformational changes; NMR; ITC.; biokemi; Biochemistry; molekylärbiologi; Molecular Biology;

    Sammanfattning : Proteins function as worker molecules in the cell and their natural environment is crowded. How they fold in a cell-like environment and how they recognize their interacting partners in such conditions, are questions that underlie the work of this thesis. LÄS MER

  4. 3. Surface Properties of Antibodies and their Complexes with Antigens Studied by LLPC

    Författare :Christer Wingren; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ligand-binding.; surface properties; isomerism; conformational changes; antibody; specificity; two-phase partitioning; antigen-binding sites; Biochemistry; Metabolism; Biokemi; metabolism;

    Sammanfattning : The main objective of this thesis was to gain further insight into the relationship between the exposed surfaces and the functional properties of antibodies and their complexes with antigens in solution. To study this relationship, a new technique, liquid-liquid partition chromatography (LLPC) in aqueous two-phase systems, was developed further with respect to sensitivity, selectivity and reproducibility. LÄS MER

  5. 4. Development of a Novel QCM Technique for Protein Adsorption Studies

    Författare :Fredrik Höök; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; viscoelastic effects; myoglobin; QCM; hemoglobin; ferritin; dissipation factor; protein adsorption; conformational changes;

    Sammanfattning : The first part of this thesis (Papers I and II) is concentrated on the development of a novel quartz crystal microbalance (QCM) technique to study protein adsorption. The second part (Papers III-V) is focused on the application of the technique on protein adsorption using well characterized surface-solution-protein systems. LÄS MER

  7. 5. A structural study of ribokinase from Escherichia coli

    Författare :Jill A. Sigrell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; ATP-binding; conformational changes; kinase; ribose; X-ray crystallography; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Ribokinase phosphorylates the abundant sugar ribose, using ATP in the presence of magnesium. The phosphorylation is the first reaction in ribose metabolism and the product, ribose-5-phosphate, can enter the pentose phosphate pathway and glycolysis. It can also be used in the synthesis of histidine and purines. LÄS MER