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1. Neruons; regulators of CNS inflammation
Sammanfattning : Neurons have been neglected as cells with major immune regulatory function. Here, we present novel data demonstrating that neurons are highly immune competent and play crucial role in regulation of T cell response and CNS inflammation. LÄS MER
2. Regulation of CNS inflammation upon T cell interaction with CNS resident cells
Sammanfattning : Multiple Sclerosis (MS), is a neurologic, autoimmune disease characterized by CNS immune cell infiltration and demyelination. To experimentally study MS, we have utilized the mouse model Experimental Autoimmune Encephalomyelitis (EAE). EAE is induced through immunization with myelin antigens, which elicits an autoreactive Th1 cell response. LÄS MER
3. Astrocytes, reactive gliosis and CNS regeneration
Sammanfattning : The regenerative capacity in the adult central nervous system (CNS) is very limited, and the glial cells have been implicated in the inhibition of CNS regeneration. In essentially all CNS pathologies, astrocytes are activated and this process is known as reactive gliosis. LÄS MER
4. Early Rostrocaudal Patterning of the CNS
Sammanfattning : The transformation of an initially uniform population of epiblast cells into an intricately complex central nervous system (CNS) is one of the most fascinating processes during embryonic development. Presumptive neural cells are initially specified as cells of forebrain character. LÄS MER
5. Astrocytes as Cellular Vehicles in Ex Vivo Gene Therapy Studies to the Rat Brain
Sammanfattning : Neurodegenerative disorders are characterized by a progressive cell-death in the brain, and loss of different functions in the patient. Today, there are no cures for any of the various diseases. Parkinson's disease is a neurodegenerative disorder with a prevalence of 0. LÄS MER