Sökning: "CIMP"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet CIMP.

  1. 1. DNA methylation signatures in precursor lymphoid neoplasms : with focus on clinical implications & the biology behind

    Författare :Zahra Haider; Sofie Degerman; Magnus Hultdin; Göran Roos; Pieter van Vlierberghe; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Acute Lymphoblastic Leukemia; Lymphoma; T-ALL; BCP-ALL; T-LBL; DNA methylation; CIMP; Prognosis; TAL1; HOX.;

    Sammanfattning : Precursor lymphoid neoplasms, namely acute lymphoblastic leukemias (ALL) and lymphoblastic lymphomas (LBL), are characterized by an aggressive proliferation of malignant progenitor B- or T-cells. To improve risk classification at diagnosis, better prognostic and treatment stratifying biomarkers are needed. LÄS MER

  3. 2. The CpG island methylator phenotype in colorectal cancer : studies on risk and prognosis

    Författare :Anna Dahlin; Richard Palmqvist; Bethany van Guelpen; Maria Henriksson; Åke Öberg; Xiao-Feng Sun; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; DNA methylation; folate; microsatellite instability MSI ; prognosis; risk factors; t-lymphocytes; the CpG island methylator phenotype CIMP ; Vitamin B12; Pathology; Patologi; Tumour biology; Tumörbiologi; patologi; Pathology;

    Sammanfattning : Background Colorectal cancer (CRC) is the second most common malignancy in developed countries. The mortality is high, with nearly half of patients dying from the disease. The primary treatment of CRC is surgery, and decisions about additional treatment with chemotherapy are based mainly on tumor stage. LÄS MER

  4. 3. DNA methylation as a prognostic marker i acute lymphoblastic leukemia

    Författare :Magnus Borssén; Sofie Degerman; Kim Vettenranta; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; acute lymphoblastic leukemia; T-ALL; Relapse; Telomere length; patologi; Pathology; Pediatrics; pediatrik;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Most ALL cases originate from immature B-cells (BCP-ALL) and are characterized by reoccurring structural genetic aberrations. These aberrations hold information of the pathogenesis of ALL and are used for risk stratification in treatment. LÄS MER

  5. 4. Further delineation of molecular alterations in adreno-medullary tumors

    Författare :Janos Geli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pheochromocytoma; abdominal paraganglioma; neuroblastoma; tumor suppressor gene; DNA methylation; gene expression; RIZ1; NORE1A; RASSF1A; CDKN2A;

    Sammanfattning : Pheochromocytomas, abdominal paragangliomas and neuroblastomas are tumors of the sympathetic nervous system. Anatomically pheochromocytomas and abdominal paragangliomas arise from sympathoadrenal paraganglia, within and outside the adrenal medulla, respectively. LÄS MER

  7. 5. Metabolic Risk Factors and Molecular Subtypes of Colorectal Cancer

    Författare :Robin Myte; Bethany van Guelpen; Richard Palmqvist; Jenny Häggström; Matty Weijenberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; risk factors; metabolic syndrome; one-carbon metabolism; molecular subtypes; KRAS; BRAF; MSI; molecular pathological epidemiology; Cancer Epidemiology; cancerepidemiologi;

    Sammanfattning : Background: Colorectal cancer (CRC) is a heterogeneous disease developing from distinct pathways, resulting in tumor subtypes with large differences in clinical and molecular characteristics. Molecular characteristics are increasingly being used clinically to guide therapy. LÄS MER