Sökning: "CHO cells"

Visar resultat 21 - 25 av 51 avhandlingar innehållade orden CHO cells.

  1. 21. On methods for probing structure and function of membrane proteins

    Författare :Erik Jansson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; proteomics; patch-clamp; mass spectrometry.; proteoliposomes; microfluidic superfusion; cholesterol; TRPV1; limited proteolysis; Membrane proteins; fluorescence;

    Sammanfattning : The determination of structure–function relationships in membrane proteins plays a key role for the understanding of molecular mechanisms in biological systems, and may provide information on how these systems can be modulated by pharmaceuticals. The aim of the work described herein was to develop methods for studying structure and function of membrane proteins, ideally in combination. LÄS MER

  3. 22. Recombinant mucin-immunoglobulin chimeras as xenoreactive anti-pig antibody absorbers

    Författare :Jining Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human allotransplantation is nowadays the generally accepted treatment of choice for several illnesses leading to organ failure. A major problem facing clinical organ transplantation is the lack of human donor organs and tissues. Xenotransplantation from pig to man is considered a plausible solution to this problem. LÄS MER

  4. 23. Studies on O-glycosylation of mucin-type proteins and their binding to antibodies, bacterial toxins and viral receptors

    Författare :Stefan Gaunitz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Carbohydrates are ubiquitous on the surface of all cells in mammals where they are involved in interactions with the surroundings (extracellular matrix), other cells (including self and non-self) and microbes (bacteria and virus). Carbohydrate-protein interactions in nature are often mediated via multivalent binding where the combined strength of multiple receptor- ligand interactions results in a binding that is highly specific and strong. LÄS MER

  5. 24. A Study on Trypanosomal Polyamine Biosynthetic Enzymes

    Författare :Sima Nasizadeh; Biogena aminer; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell cycle; protein turnover; trypanosomatids; polyamines; Ornithine decarboxylase; S-adenosylmethione decarboxylase; Parasitology human and animal ; Parasitologi människa och djur ;

    Sammanfattning : The polyamines, putrescine, spermidine, and spermine, are essential for all forms of life. The polyamine biosynthetic pathway has been shown to be a potential target for drugs against various trypanosomal parasitic diseases. LÄS MER

  7. 25. Platelet-regulated CD4+ T effector cell responses in atherosclerosis

    Författare :Shuai Tan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis (AS) is a thrombotic and inflammatory disease of the medium- and largesized arteries. Platelets participate in all stages of its formation, forming thrombus at the ruptured plaque; meanwhile, CD4+ T cells are a key driving force of inflammation, plaque formation and instability. LÄS MER