Sökning: "CDKN2A"

Visar resultat 16 - 20 av 52 avhandlingar innehållade ordet CDKN2A.

  1. 16. Cancer risks and prognosis in familial melanoma kindreds

    Författare :Hildur Björg Helgadóttir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant melanoma of the skin is one of the most rapidly increasing cancers in many western countries, including Sweden. This incidence rise is mainly attributed to sun-seeking habits with increased intermittent UVR exposure, a major risk factor for melanoma. LÄS MER

  3. 17. Cell cycle regulatory genes in human astrocytic tumors

    Författare :Koichi Ichimura; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is a genetic disorder of somatic cells. Neoplastic transformation and malignant progression may be a consequence of accumulated multiple genetic changes in a cell. Astrocytic gliomas are the commonest brain tumors in humans. LÄS MER

  4. 18. Understanding the response to EGFR targeting therapy in non-small-cell lung cancer using -omics approach

    Författare :Yan Zhou Tran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : NSCLC is the leading cause of cancer-related death worldwide. EGFR targeted therapy is used to inhibit the progress of NSCLC, but patients inevitably develop resistance to EGFRTKIs. LÄS MER

  5. 19. Alterations of cell cycle control genes in human astrocytomas

    Författare :Esther E Schmidt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytogenetic analyses and molecular genetic studies have revealed a number of chromosomal regions deleted or amplified in astrocytic tumors, presumably harboring tumor suppressor genes and oncogenes involved in astrocytic oncogenesis. Astrocytomas represent the most common subgroup of primary intracranial tumors. LÄS MER

  7. 20. Mutations and molecular signatures in human melanoma

    Författare :Braslav Jovanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cutaneous melanoma is a disease which results from a complex mixture of various extrinsic and intrinsic factors, with some major players still unknown. Although primary tumors are highly curable with surgical excision, particularly those which are non-ulcerated and have a thickness of less than 1 mm, poor survival rates are observed in advanced disease. LÄS MER