Sökning: "CDKN2A"

Visar resultat 11 - 15 av 52 avhandlingar innehållade ordet CDKN2A.

1. 11. Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers

   Författare :Johanna Smeds; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :CDKN2A; ARF; p53; cell cycle regulation; mutation; melanoma; esophageal squamous cell carcinoma;

   Sammanfattning : The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents a unique locus in the entire human genome. LÄS MER

3. 12. Molecular changes in the tumour suppressor genes p53 and CDKN2A/ARF in human urinary bladder cancer

   Författare :Petra Berggren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Urinary bladder neoplasm is the ninth most common cancer in Europe and the United States. The incidence in Sweden is approximately 32 for men and 9 for women per 105 subjects and year and almost all cases are transitional cell carcinoma (TCC). LÄS MER

4. 13. Further delineation of molecular alterations in adreno-medullary tumors

   Författare :Janos Geli; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Pheochromocytoma; abdominal paraganglioma; neuroblastoma; tumor suppressor gene; DNA methylation; gene expression; RIZ1; NORE1A; RASSF1A; CDKN2A;

   Sammanfattning : Pheochromocytomas, abdominal paragangliomas and neuroblastomas are tumors of the sympathetic nervous system. Anatomically pheochromocytomas and abdominal paragangliomas arise from sympathoadrenal paraganglia, within and outside the adrenal medulla, respectively. LÄS MER

5. 14. Malignant melanoma in children and adolescents

   Författare :Peter Berg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Melanoma; epidemiology; cancer register; children; adolescents; incidence; phototherapy; hyperbilirubinaemia; etiological factors; congenital nevi; heredity; CDKN2A; germline mutation.;

   Sammanfattning : The aim of the work reported in the present thesis was to investigate malignant melanoma in children and adolescents. Through epidemiological studies, we wished to investigate incidence, clinical factors and prognosis and to study the records. LÄS MER

7. 15. Functional characterization of the alternative reading frame protein p14ARF

   Författare :Mikael Lindström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :p14ARF; p19ARF; alternative reading frame; CDKN2A; p53; B23; nucleophosmin; Burkitt´s lymphoma; nucleolus; senescence; Myc; E2F; phosphorylation; RNA interference; ribosome biogenesis;

   Sammanfattning : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. LÄS MER