Sökning: "CDK4"

Visar resultat 6 - 10 av 33 avhandlingar innehållade ordet CDK4.

  1. 6. Proliferation, Invasion and p16 Localisation in Malignancies

    Författare :Kristina Nilsson; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; Cytologi; cancerology; Cytology; oncology; skin tumours; invasion; p16; cancer; patologisk anatomi; Patologi allmän ; pathological anatomy; proliferation; General pathology;

    Sammanfattning : Uncontrolled proliferation and invasion are two characteristics in tumour development and progression. Previous studies have shown that invading tumour cells in colorectal cancer have low proliferation in parallel to upregulation of the tumour suppressor p16. LÄS MER

  3. 7. Cell cycle genes in chondrosarcoma. Involvement of the Id1 and p16 pathways

    Författare :Julia Asp; Göteborgs universitet; []
    Nyckelord :chondrosarcoma; articular chondrocytes; cell cycle; p16; Id1; helix-loop-helix;

    Sammanfattning : Chondrosarcoma is a malignant, cartilaginous tumour arising from bone. The wide variationin morphology, behaviour and clinical outcome raise the question whether chondrosarcomasare several different but closely related tumours rather than a single entity. LÄS MER

  4. 8. Array based genetic profiling of bone and soft tissue tumors

    Författare :Karolin Hansén Nord; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In this thesis, genetic alterations in bone and soft tissue tumors have been investigated with the purpose of identifying regions of importance for tumor development, diagnosis and prognosis. This has primarily been performed by array comparative genomic hybridization analysis and gene expression profiling of cytogenetically analyzed tumors. LÄS MER

  5. 9. The cell cycle regulators p18Ink4c and p19Ink4d : in vivo studies of their roles in tumorigenesis and development

    Författare :Lisa Nilsson; Olle Heby; Martine Roussel; Klas Wiman; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi;

    Sammanfattning : Progression through the G1, S, G2 and M phases of the cell cycle is controlled by cyclin-dependent kinases (Cdks) and cyclins. These proteins form active Cdk:cyclin complexes that phosphorylate specific substrates. LÄS MER

  7. 10. Germline CDKN2A/ARF alterations in human melanoma

    Författare :Jamileh Hashemi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial melanoma; germline mutation; CDKN2A; p16; p14ARF; cell cycle;

    Sammanfattning : Approximately 10% of cases of human cutaneous malignant melanoma (CMM) have been estimated to occur in individuals with a familial predisposition, frequently in association with dysplastic nevus syndrome (DNS). The genetics of familial melanoma is complex and heterogeneous. To date only two melanoma predisposing genes have been identified. LÄS MER