Sökning: "CDK4"

Visar resultat 11 - 15 av 33 avhandlingar innehållade ordet CDK4.

  1. 11. Predictive markers for tamoxifen response in primary breast cancer

    Författare :Maria Stendahl; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; General pathology; Cytologi; onkologi; prognosis; Cytology; oncology; cancerology; predictive marker; p27; cyclin D1; tamoxifen; PR; breast cancer; ER; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Sammanfattning : It is well-known that a majority of breast cancers are hormone-dependent, making endocrine therapy an important adjuvant treatment after surgery. Susceptibility to endocrine treatment is determined by the presence of estrogen receptors (ER) and progesterone receptors (PR) in the tumors. LÄS MER

  3. 12. Genomic and Transcriptomic Analyses of Osteogenic Tumours of Bone

    Författare :Karim Saba; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Primary tumours of bone are heterogenous and infrequent neoplasms. Distinguishing between benign, intermediate and malignant entities can in some instances pose a clinical challenge. For some tumour types, there is still much to be learned about the genetic mechanisms that give rise to and drive these tumours forward. LÄS MER

  4. 13. Alterations of cell cycle control genes in human astrocytomas

    Författare :Esther E Schmidt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytogenetic analyses and molecular genetic studies have revealed a number of chromosomal regions deleted or amplified in astrocytic tumors, presumably harboring tumor suppressor genes and oncogenes involved in astrocytic oncogenesis. Astrocytomas represent the most common subgroup of primary intracranial tumors. LÄS MER

  5. 14. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system

    Författare :Yinghua Zhou; Uppsala universitet; []
    Nyckelord :Medical sciences; interferon-α; carcinoid tumors; interferon regulatory factor; p68; PKR; p21; p27; cell cycle; cyclin-dependent kinase; protein phosphorylation; protein trafficking; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. LÄS MER

  7. 15. The epidemiology, biology and genetics of human astrocytic tumours

    Författare :Magnus Bäcklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cancer; cell cycle; apoptosis; astrocytic glioma; glioblastoma; Rb 1 pathway; p53 pathway; EGFR; PTEN; prognosis; parathyroid adenoma; epidemiology;

    Sammanfattning : In Sweden > 1000 primary central nervous system (CNS) tumours are diagnosed each year. The majority are malignant and in adults astrocytic gliomas dominate. LÄS MER