Sökning: "CD8"
Visar resultat 11 - 15 av 411 avhandlingar innehållade ordet CD8.
11. MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
Sammanfattning : The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats by scanning a repertoire of peptide epitopes presented by major histocompatibility complex (MHC) molecules. LÄS MER
12. Smoking and T cell co-stimulation in rheumatoid arthritis
Sammanfattning : In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. LÄS MER
13. Adaptive immune responses in atherosclerosis - or how to prolong the use of your yellow socks
Sammanfattning : Abstract Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. LÄS MER
14. Recognition by and escape from CD8+ T cell immune surveillance in cancer bearing hosts
Sammanfattning : CD8+ T cells ( TCD8+ ) can specifically recognize tumor cells through MHC class I molecules associated with peptides that are 8-l0 amino acid residues long. In recent years, a number of tumor-associated antigens, or their epitopes, have been identified and characterized with the advent of new methods in molecular biology and in peptide isolation. LÄS MER
15. Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
Sammanfattning : The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. LÄS MER