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Visar resultat 1 - 5 av 318 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Generation of Therapeutic T Cells for Prostate Cancer

    Författare :Ole Forsberg; Magnus Essand; Thomas Tötterman; Gustav Gaudernack; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; T cells; dendritic cells; peptides; cytomegalovirus; adenovirus; immunotherapy; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : The work presented herein focuses on the activation of the adaptive immune system in order to develop T cell-based immunotherapy for viral infections and cancer. The main goal was to identify and activate viral or tumoral antigen-specific T cells by using different identification, isolation and stimulation techniques. LÄS MER

  3. 2. Immunity to Rotavirus infection across ages

    Författare :Konjit Getachew Muleta; Virusrekognition; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rotavirus; B cells; T cells; Dendritic cells; Mesenteric Lymph Node; CD8 T cells; Maternal protection; IgA; Neonates; Small Inestinal lamina propria; IFNAR signaling;

    Sammanfattning : Rotavirus (RV) is a double-stranded RNA virus that mainly affects young children under the age of five years. It is one of the leading causes of dehydrating gastroenteritis. Every year, about 200,000 child deaths occur due to RVinfection. Vaccines exist and are in use worldwide. LÄS MER

  4. 3. Human intraepithelial lymphocytes : a comparative study of phenotype, morphology, and functional properties of intraepithelial lymphocytes in gut and oral mucosa

    Författare :Carina Lundqvist; Marie-Louise Hammarström; Sten Hammarström; Per Brandtzaeg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intraepithelial lymphocytes; alimentary tract; intestinal epithelium; gut luminal antigens; gingiva; γδ T cells; immunoelectron microscopy; cytokine mRNA; RT-PCR; extrathymic T cell maturation; RAG-1; periodontitis; mucosal immune system; CD4-CD8- αβ T cells; CD8 γδ T cells;

    Sammanfattning : Human intraepithelial lymphocytes (IEL) constitute a unique cell population situated in the first line of defense of the alimentary tract. Here they are continuously exposed to a massive antigenic load of high complexity. However, different conditions prevail along the alimentary tract. LÄS MER

  5. 4. Infection induced chronic inflammation and it's association with prostate cancer initiation and progression

    Författare :Sabina Davidsson; Ove Andrén; Bo Söderquist; Jennifer Rider; Gisela Helenius; Jan-Erik Damber; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; chronic inflammation; CD4 helper T cells; CD8 cytotoxic T cells; regulatory T cells; Propionibacterium acnes; Medicine; Medicin;

    Sammanfattning : An association between cancer development and inflammation has long been suggested. Approximately 20% of all human cancers in adults are assumed to result from chronic inflammation. The aim of this thesis was to investigate if infection-induced chronic inflammation plays a role in prostate carcinogenesis. LÄS MER

  7. 5. Regulatory CD4+FOXP3+ T cells in Helicobacter pylori-induced disease

    Författare :Bert Kindlund; Göteborgs universitet; []
    Nyckelord :Regulatory T cells; Helicobacter pylori; duodenal ulcer; gastric cancer; FOXP3;

    Sammanfattning : Helicobacter pylori colonize the gastric or duodenal mucosa of approximately half of the worlds’ population. Although most individuals are asymptomatic, H. pylori infection cause peptic ulcers or gastric cancer in 10-15 % and 1-2 %, respectively, of the infected individuals. LÄS MER