Sökning: "CD63"

Visar resultat 6 - 10 av 18 avhandlingar innehållade ordet CD63.

  1. 6. Innovative approaches to study basophil function in inflammation

    Författare :Zenib Aljadi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Basophils are circulating granulocytes. They are very rare and represent less than 1% of peripheral blood leukocytes. Basophils connect the innate and adaptive immune responses by the secretion of a variety of immune-mediators involved in the pathogenesis of many inflammatory diseases mainly allergic reactions and autoimmune diseases. LÄS MER

  3. 7. Studies of cell-on-chip technology and basophil regulation for improved allergy diagnostics

    Författare :Frida Kalm; Anna Nopp Scherman; Stephanie Descroix; KTH; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Medical Technology; Medicinsk teknologi;

    Sammanfattning : Allergic diseases affect approximately 30% of adults and has an impact on both the individual’s quality of life as well as an economic impact on society. Two effector cells involved in allergic disease are mast cells and basophils, where basophils are more readily available in blood and therefore of great interest when studying allergy. LÄS MER

  4. 8. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

    Författare :Ying Gao; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; extracellular fluids; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

    Sammanfattning : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. LÄS MER

  5. 9. Inflammation modulating effects of prostaglandins and omega-3 fatty acids

    Författare :Inger Vedin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Omega-(omega6) and omega-3 fatty acids (FA) and their metabolites (eikosanoids, such as prostaglandins, PG) are important modulators of immune and inflammatory responses in various ways. The aim of this thesis was to assess some in vitro and ex vivo effects of these lipids on blood leukocytes. LÄS MER

  7. 10. Exosomes in immune regulation and allergy

    Författare :Charlotte Admyre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Exosomes are nano-sized vesicles of endosomal origin which are secreted from several different cell types. Depending on their cellular source they have been suggested to have different functions, like having a role in antigen delivery and T cell activation (antigen presenting cell-derived exosomes) or a role in tolerance induction (epithelial cell-derived exosomes). LÄS MER