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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.
1. Towards Personalized Cancer Therapy : New Diagnostic Biomarkers and Radiosensitization Strategies
Sammanfattning : This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. LÄS MER
2. Precision medicine and targeted therapy : Turning the tables on cancer
Sammanfattning : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). LÄS MER
3. Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma
Sammanfattning : To personalize treatment for cancer, correct staging of the primary tumor, nodal disease and metastatic disease is of essence. By targeting tumor specific receptors with radiolabeled antibodies, specificity and accuracy of imaging may be improved. LÄS MER
4. Diagnosis and Radioimmunotherapy of Head and Neck Squamous Cell Carcinomas
Sammanfattning : The diagnosis and treatment of patients with advanced tumors in the head and neck is an interesting challenge where there is a need for new approaches in diagnostics and adjuvant treatment. Differences in antigen expression between tumors and normal tissues provide a means for application of antibody-based targeting techniques. LÄS MER
5. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy : Preclinical Studies on Head and Neck Cancer
Sammanfattning : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. LÄS MER