Sökning: "CD40L promoter"

Hittade 3 avhandlingar innehållade orden CD40L promoter.

  1. 1. B cell activation in vitro: thymus-dependent immune responses and bacterial cell surface proteins

    Författare :Karol Axcrona; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear transport; bacterial Ig-binding proteins; CD40L promoter; CD21; Ig; B lymphocyte activation in vitro; CD40; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : In this thesis aspects of peripheral B lymphocyte differentiation were studied. Through in vitro experiments, B lymphocyte activation was assessed. B lymphocytes express immunoglobulin (Ig) specific for a certain antigen on the cell surface, and when surface Ig is crosslinked by an antigen, the cell is activated. LÄS MER

  3. 2. Adenovirus-mediated CD40 Ligand Immunotherapy of Prostate and Bladder Cancer

    Författare :Helena Dzojic; Magnus Essand; Thomas H Tötterman; Aristides Eliopoulos; Uppsala universitet; []
    Nyckelord :Medicine; immunotherapy; gene therapy; prostate cancer; bladder cancer; adenoviral vector; CD40 ligand; promoter; PPT; TSTA; depsipeptide FK228; TRAMP-C2; Medicin;

    Sammanfattning : Cancer immunotherapy aims at reversing the immunosuppressive tumor environment and enhancing anti-tumor immunity. This thesis comprises studies on murine models for prostate (TRAMP-C2) and bladder (MB49) cancer with the aim to explore if the introduction of an adenoviral vector expressing CD40 ligand (AdCD40L) can induce anti-tumor immune responses. LÄS MER

  4. 3. Regulatory mechanisms contributing to the homeostasis of normal and malignant hematopoietic cells

    Författare :Harsha Madapura Sekharappa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bone marrow is the site of origin of diverse population of hematological cells with lineage specific function. The different lineages of cells originate from a common progenitor that has a strong self-renewable capability giving rise to myeloid and lymphoid progenitor cells. LÄS MER