Sökning: "CD40"

Visar resultat 21 - 25 av 89 avhandlingar innehållade ordet CD40.

  1. 21. Vascular targeting for enhanced cancer immunotherapy

    Författare :Maria Georganaki; Anna Dimberg; Sara Mangsbo; Lena Claesson-Welsh; Wolf Hervé Fridman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; tumor vasculature; endothelial activation; IDO1; ELTD1; tertiary lymphoid organ; Biologi; Biology;

    Sammanfattning : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. LÄS MER

  3. 22. Transcription factors regulating the immunoglobulin heavy chain locus

    Författare :Tove Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immunoglobulin heavy (IgH) chain locus is subject to somatic recombination and changes in gene expression in B lineage cells. Enhancers located in the 3' end of the locus may in part regulate these events. This work aimed at increasing the understanding of the function of one of these elements, the HS1,2 enhancer. LÄS MER

  4. 23. Regulation of germline transcription in the immunoglobulin heavy chain locus

    Författare :Jurga Laurencikiene; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During an immune response, activated B cells develop into high rate immunoglobulin (Ig) secreting plasma cells. They also switch from production of IgM to IgG, IgA or IgE. Specific isotypes of antibodies have functional and structural features that make them particularly well suited to defend against different types of pathogens. LÄS MER

  5. 24. Regulation of lymphocyte activation and death

    Författare :Hanna Lindgren; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; N-substituted benzamides; apoptosis; NF-kB; NFAT; T cells; CD40L; serology; transplantation; Immunologi; serologi;

    Sammanfattning : T lymohocytes (T cells) and B lymphocytes (B cells) are important effector cells of the adaptive immune system. In response to infections, B cells are activated and produce antibodies against specific antigens. LÄS MER

  7. 25. Antibody-based Cancer Immunotherapy : Personalization, response prediction and safety considerations

    Författare :Mohamed Eltahir; Sara Mangsbo; Patrick Micke; Gustav Ullenhag; Marit Inderberg; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Antibody-based therapeutics have remarkably improved the field of immuno-oncology. Multiple monoclonal antibodies (mAbs) are approved for clinical use, and numerous antibodies are under clinical development. The scope of this thesis is to study the personalization of antibody-based immunotherapeutics and tools to predict their efficacy and safety. LÄS MER