Sökning: "CD4 cell counts"

Visar resultat 1 - 5 av 43 avhandlingar innehållade orden CD4 cell counts.

  1. 1. HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau

    Författare :Joakim Esbjörnsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV-2; Guinea-Bissau; subtype; disease progression; evolution; coreceptor tropism; CXCR4; gp120; V1-V3; CD4%; CD8%; soluble immune markers;

    Sammanfattning : The two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. LÄS MER

  3. 2. Sarcoidosis : expression of cell regulatory markers and the influence of patient phenotype on bronchoalveolar lavage cell differential counts

    Författare :Muntasir Abo Al Hayja; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sarcoidosis is a systemic inflammatory disease that can affect almost any organ, but the respiratory system is affected in more than 90% of the cases. To elicit an immune response, an antigen(s) is processed by antigen-presenting cells (APCs), e.g. LÄS MER

  4. 3. Mesenchymal stromal cell crosstalk with the immune system

    Författare :Caroline Gavin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell therapy is a promising treatment for several diseases. One of the most commonly used cell types are mesenchymal stromal cells (MSCs). MSCs are found in most connective tissues but for clinical use they are commonly harvested from bone marrow, adipose tissue and umbilical cord. LÄS MER

  5. 4. Flow cytometric methods for assessment of cell-mediated immune responses

    Författare :Karina Godoy Ramirez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Flow cytometry; intracellular cytokine staining ICS ; NK cell; CTL; cytotoxicity; HIV-1;

    Sammanfattning : The aim of this thesis was to develop and improve flow cytometry-based methods for assessment of cellmediated immune responses (CMI) induced by natural infection or vaccination. Traditionally, the measurement of anti genspecific cellular immune responses has been based on the use of complex, labourintensive, and less informative bulkresults assays (51Cr-release, 3 3H-thymidin uptake and Limiting dilution assay, LDA). LÄS MER

  7. 5. The central role of the CD4 T-helper cell in HIV infection : analysis of cell mediated responses and CCR-5 genotypes in HIV-1 infected individuals

    Författare :Ann-Charlotte Leandersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human immunodeficiency virus (HIV) infection is characterized by progressive immunologic dysregulation. The main target of HIV is the CD4 cell resulting in malfunction of the immune system, with a decline in CD4 cells and subsequent development of the acquired immunodeficiency syndrome (AIDS). LÄS MER