Sökning: "CD4 CD25"

Visar resultat 6 - 10 av 50 avhandlingar innehållade orden CD4 CD25.

  1. 6. Phenotype and function of CD25+ regulatory T cells in infants and adults

    Författare :Hanna Grindebacke; Göteborgs universitet; []
    Nyckelord :Immunology; CD4 CD25 FOXP3 regulatory T cells; human; allergy; IL-10; Systemic immunotherapy; migration; homing receptors; maturation;

    Sammanfattning : Active suppression by CD4+CD25+FOXP3+ regulatory T cells (Treg) is essential for the maintenance of peripheral tolerance to both self antigens and environmental antigens. Absence of these cells in human newborns leads to autoimmune and inflammatory disorders as well as allergic disease. LÄS MER

  3. 7. Inhibition of T cell responses to autoantigens and allergens by CD25+ regulatory T cells from thymus, cord and adult blood

    Författare :Kajsa Wing; Göteborgs universitet; []
    Nyckelord :Tolerance; CD25 regulatory T cells; adult peripheral blood; cord blood; thymus; autoimmune disease; allergy;

    Sammanfattning : Autoimmune diseases and allergies are a growing problem in the western world today. Tolerance is primarily established by clonal deletion in the thymus. Despite this auto-reactive T cells are normally present in most individuals, which suggests that mechanisms of peripheral tolerance operate to silence potentially pathogenic T cells. LÄS MER

  4. 8. Regulatory CD4+FOXP3+ T cells in Helicobacter pylori-induced disease

    Författare :Bert Kindlund; Göteborgs universitet; []
    Nyckelord :Regulatory T cells; Helicobacter pylori; duodenal ulcer; gastric cancer; FOXP3;

    Sammanfattning : Helicobacter pylori colonize the gastric or duodenal mucosa of approximately half of the worlds’ population. Although most individuals are asymptomatic, H. pylori infection cause peptic ulcers or gastric cancer in 10-15 % and 1-2 %, respectively, of the infected individuals. LÄS MER

  5. 9. Lineage stability and effector function of CD4+FOXP3+ regulatory T cells

    Författare :Christina Seitz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Treg cells are crucial in maintaining immunological tolerance and they in part act by suppressing dendritic cells (DCs). LÄS MER

  7. 10. Helicobacter pylori infection and immunity. Protection after vaccination and regulation of inflammation in a mouse model

    Författare :Sukanya Raghavan; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter pylori; formalin-inactivated H. pylori; post-immunization gastritis; cholera toxin; CD4 CD25 regulatory T cells; CpG ODN;

    Sammanfattning : Helicobacter pylori infection is an important cause of chronic active gastritis and peptic ulcer disease and a risk factor for the development of gastric cancer. An attractive strategy in the control of H. pylori infection is the development of a safe and effective therapeutic vaccine. Using a mouse model of H. LÄS MER