Sökning: "CD39"

Visar resultat 6 - 10 av 13 avhandlingar innehållade ordet CD39.

  1. 6. Regulatory T cells in rheumatoid arthritis : contributions from different functional subsets

    Författare :Jessica Alexandra Herrath; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a complex and multifactorial disease characterized by chronic joint inflammation and tissue destruction, which can affect all ethnic groups with a prevalence of 0.5-1%. LÄS MER

  3. 7. Art of tumor immunity : extricating hypoxia-driven immunosuppression in the solid tumor microenvironment

    Författare :Apple Tay; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The fate of tumors, from initiation to in situ carcinoma and ultimately metastasis, is intricately tied to the balance between the immune system’s effector cytotoxic and tolerogenic immunosuppressive responses, collectively known as tumor immunity. However, this balance is disrupted by hypoxia, a common characteristic of solid tumors, which drives immunosuppression and contributes to the heterogeneity of the solid tumor microenvironment (TME). LÄS MER

  4. 8. The importance of psychological and physical stressors on diabetes-related immunity in a young population – an interdisciplinary approach

    Författare :Emma Carlsson; Maria Faresjö; Arne Gerdner; Anneli Frostell; Kristina Lejon; Jönköping University; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; psychological stressors; physical stressors; cellular immune system; type 1 diabetes; young population;

    Sammanfattning : Background: The prevalence of immunological disorders such as type 1 diabetes (T1D) is increasingly common amongst children, adolescents and young adults. There is also an increase in psychosomatic symptoms (depression, insomnia, anxiety, headaches and fatigue etc. LÄS MER

  5. 9. Regulation of immunity in Multiple Sclerosis : CD4+ T cells and the influence of natalizumab

    Författare :Måns Edström; Jan Ernerudh; Maria Jenmalm; Charlotte Dahle; Finn Sellebjerg; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system (CNS) and the most common neurological cause of disability in young adults. In most cases, the disease course is characterised by the cycling of relapses and remissions, so called relapsing-remitting MS (RR-MS). LÄS MER

  7. 10. G1-phase cyclin expression in neoplastic B cells

    Författare :Richard Scuderi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle; G1 phase; cyclin D; cyclin E; EBV; Burkitt s; B-ALL; B-CLL; apoptosis;

    Sammanfattning : By virtue of the role of G1-phase cyclin proteins as regulators of differentiation, proliferation, and apoptosis, their improper expression can lead to altered cellular homeostasis and tumor formation. Cyclins provide the regulatory partner for cyclin-cdk complexes whose enzymatic activity drives cell cycle progression. LÄS MER