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Visar resultat 1 - 5 av 23 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Heparan Sulfate Proteoglycans in Brain Tumor Development

    Författare :Argyris Spyrou; Karin Forsberg Nilsson; Fredrik Johansson Swartling; Jöns Hilborn; John Couchman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; pediatric brain tumors; heparanase; NDST1; heparan sulfate proteoglycans; CD24; glycosaminoglycan mimetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Malignant brain tumors are aggressive neoplasms that remain challenging to treat in spite of their detailed molecular characterization. Both adults and children may suffer from brain tumors, which, if not lethal, can cause severe long-term and devastating side effects. LÄS MER

  3. 2. Stem and progenitor cells in brain ad breast malignancies

    Författare :Gabriella Honeth; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural progenitor cells; glioma; migration; chemokines; cancer stem cells; breast cancer; CD44; CD24;

    Sammanfattning : Stem cells have qualities that clearly distinguish them from all other cells. Capabilities like self-renewal, differentiation and migration make them truly powerful. This thesis deals with different aspects of stem/progenitor cells in relation to cancer. LÄS MER

  4. 3. Novel methods of malignant brain tumor treatment utilizing the tumor microenvironment

    Författare :Jan Kopecky; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain tumors; Glioblastoma; Medulloblastoma; Convection-enhanced delivery; Antisecretory factor; AF16; Salovum; Macrophages; Immunology; Cancer; CD24; Siglec10; Antiphagocytic signaling;

    Sammanfattning : Malignant brain tumors constitute a disaster in the lives of patients, either in the form of extremely low survival in glioblastoma, or the serious long-term adverse effects of therapy in medulloblastoma. These two tumor types represent the most common malignant brain entities in adults and children, respectively. LÄS MER

  5. 4. Functional genetic studies of Psoriasin: a potential biomarker for breast cancer with a poor prognosis

    Författare :Stina Petersson; Göteborgs universitet; []
    Nyckelord :Psoriasin; Breast cancer; Reactive oxidant species; NF-κB; IFNγ; STAT1; ICAM-1; MUC1; CD24;

    Sammanfattning : Breast cancer is the most common malignancy in women. There is a high degree of heterogeneity in breast tumours and they can be divided into subtypes that have different expression pattern and clinical outcome. Ductal Carcinoma in situ (DCIS) is regarded as a precursor of invasive ductal breast cancer. LÄS MER

  7. 5. EWSR1 and FUS fusion genes in tumorigenesis

    Författare :Emely Möller; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The present thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins they encode, in tumorigenesis. In Article I, the EWSR1 promoter, which regulates the expression of EWSR1 fusion genes, was characterized and regions that were crucial for promoter activity could be identified. LÄS MER