Sökning: "CD1d"
Visar resultat 6 - 10 av 25 avhandlingar innehållade ordet CD1d.
6. Genetics and functions of innate-like lymphocyte subsets
Sammanfattning : The immune system contains three different branches: innate immunity, adaptive immunity and innate-like lymphocytes that share properties both with the innate and adaptive immune cells. The innate-like lymphocytes have the capacity to rapidly become activated by invading pathogens and also to modulate immune responses and thereby inhibit or promote inflammation. LÄS MER
7. CD1d restricted NKT cells in regulation of pathogenic autoimmunity
Sammanfattning : Human autoimmune diseases such as reumatoid arthritis (RA) and multiple sclerosis (MS) are believed to develop when self-tolerance mechanisms are failing, with a chronic destructive inflammation as result. To experimentally study autoimmunity, we have used murine models that mimic their human counterparts; experimental autoimmune encephalomyelitis (EAE) – a model for MS, and collagen induced arthritis (CIA) and antigen induced arthritis (AIA) – models for RA. LÄS MER
8. Invariant NKT cells and CD1d in HIV-1 infection
Sammanfattning : The invariant natural killer T (iNKT) cells are a subset of T lymphocytes that share characteristics of both innate and adaptive immunity. These cells are defined as T cells restricted by the lipid antigen presenting molecule CD1d and express an invariant T cell receptor (TCR) as well as classical natural killer (NK) cell markers. LÄS MER
9. Immunomodulation in atherosclerosis : impact of Th balance and CD1d-restricted NKT cells
Sammanfattning : Atherosclerosis is a slow and progressive disease consisting of lipid deposition in arterial walls. Studies in both human and experimental animal models have shown the involvement of the immune system in the pathogenesis. LÄS MER
10. Regulation of CNS inflammation upon T cell interaction with CNS resident cells
Sammanfattning : Multiple Sclerosis (MS), is a neurologic, autoimmune disease characterized by CNS immune cell infiltration and demyelination. To experimentally study MS, we have utilized the mouse model Experimental Autoimmune Encephalomyelitis (EAE). EAE is induced through immunization with myelin antigens, which elicits an autoreactive Th1 cell response. LÄS MER