Sökning: "CCR2"

Visar resultat 6 - 10 av 23 avhandlingar innehållade ordet CCR2.

  1. 6. Dynamics of HIV coreceptors and their utilization by plasma and cerebrospinal fluid HIV-1 isolates

    Författare :Ulf Karlsson; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : HIV-1 infection of CD4+ immune cells requires the assistance of cellular coreceptors. The regulation of these receptors is highly dynamic. In addition to the major coreceptors, CCR5 and CXCR4, several alternative coreceptors mediate entry for selected HIV isolates in vitro, although their role in vivo is yet to be established. LÄS MER

  3. 7. Immunological mechanisms in systemic autoimmunity : autoantibodies and chemokines in systemic lupus erythematosus and during treatment with TNF inhibitors in rheumatoid arthritis

    Författare :Catharina Eriksson; Karl-Gösta Sundqvist; Solbritt Rantapää-Dahlqvist; Mari Norgren; Thomas Skogh; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; chemokines; T-cells; autoantibodies; CD91; Clinical immunology; Klinisk immunologi; Rheumatology; Reumatologi; Clinical Immunology; klinisk immunologi; reumatologi; rheumatology;

    Sammanfattning : Background. Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease that, without powerful treatment, may lead to irreversible joint damage. During the past decade, anti-cytokine therapy has become available, e.g. LÄS MER

  4. 8. Excitotoxic neurodegeneration in mouse brain : roles of immune cells and cytokines

    Författare :Zhiguo Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Excitotoxic neurodegeneration is a common feature in many neurological diseases. However, the roles of immune cells and cytokines in this process are unclear. To address this issue, we used knockout (KO) mice deficient in various immune cells or cytokines in our studies. LÄS MER

  5. 9. Vascular progenitor cells in arterial remodeling

    Författare :Monika K Grudzinska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease is the leading cause of global mortality and physical disability mainly due to the complications such as myocardial infarction or stroke. Physiological healing reaction takes place in the diseased vessel wall aimed to repair the vessel after an injury. LÄS MER

  7. 10. Molecular monitoring of acute graft-versus-host disease after allogenic stem cell transplantation

    Författare :Marie Jaksch; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Stem Cell Transplantation; Acute Graft-versus-host disease; FasL; Granzym B; Chemokine receptors; chimerism;

    Sammanfattning : Acute graft-versus-host disease (GVHD) remains a major barrier to the wider application of allogeneic stem cell transplantation (SCT) for a variety of diseases. GVHD occurs when the transplanted donor Tlymphocytes react to host antigens on antigen-presenting cells and attack host tissues. LÄS MER