Sökning: "CCK receptor antagonists"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden CCK receptor antagonists.
1. Effect of Cholecystokinin-B/Gastrin Receptor Antagonists on Rat Stomach ECL Cells
Sammanfattning : The histamine- and pancreastatin- containing ECL cells in the acid-producing mucosa of the rat stomach operate under the control of circulating gastrin. The present work examines how cholecystokinin (CCK)-B/gastrin receptors regulate the activity of the ECL cells. LÄS MER
2. The cholecystokinin receptor family : molecular cloning and pharmacological characterization
Sammanfattning : Cholecystokinin (CCK) and gastrin are hormones/neurotransmittors of the gastrointestinal tract and central nervous system. The receptors for gastrin and CCK are members of the G protein-coupled receptor family. The aim of this study was to clone and pharmacologically characterize vertebrate and invertebrate CCK receptors and splice variants. LÄS MER
3. The Gastrin-ECL Cell Axis. Functional Aspects
Sammanfattning : The ECL cells constitute a prominent endocrine cell population in the acid-producing part of the stomach. They are controlled by circulating gastrin released from G-cells in the antrum. In response to gastrin, they secrete histamine, that in turn stimulates the parietal cell to secrete acid. LÄS MER
4. Peripherally administered choleocystokinin-8 increases neurotrophins in the brain
Sammanfattning : The aim of this thesis was to test the hypothesis that the gastric hormone Cholecystokinin-8 (CCK-8) can modulate the production of Nerve Growth Factor (NGF) in the brain. NGF is the first discovered and the best characterized neurotrophic factor which plays a crucial role in the survival and development of basal forebrain cholinergic neurons (BFCN). LÄS MER
5. On cholecystokinin-opioid interaction in the spinal dorsal horn following peripheral nerve injury and inflammation
Sammanfattning : The peptide cholecystokinin (CCK) antagonizes opioid-induced analgesia. Conversely, antagonists of CCK receptors enhance the analgesic effect of opioids. Together, these results support a role for CCK as an anti-opioid peptide in pain mechanisms. LÄS MER