Sökning: "CBF?"

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet CBF?.

1. 1. Structure-function relationships of the human Runx1 transcription factor

   Författare :Magnus Wolf-Watz; KTH; []
   Nyckelord :Runx1; Runt domain; CBFâ; transcription; leukemia; protein structure; protein dynamics;

   Sammanfattning : Runx transcription factors contain a DNA-binding andtransactivating α-subunit and a β-subunit (CBFβ)that serves to increase the DNA binding affinity of theα-subunit. The DNA binding domain of Runx proteins isnamed the Runt homology domain (RD) after its strong sequencehomology to theDrosophilaprotein Runt. LÄS MER

3. 2. The hematopoietic transcription factor RUNX1 : a structural view

   Författare :Stefan Bäckström; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; RUNX1; Runt domain; CBFβ; transcription factor; leukaemia; protein crystallography; anomalous diffraction; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylärbiologi; Molecular Biology;

   Sammanfattning : The malfunction of the transcriptional regulator RUNX1 is the major cause of several variants of acute human leukemias and its normal function is to regulate the development of the blood system in concert with other transcriptional co-regulators. RUNX1 belongs to a conserved family of heterodimeric transcription factors that share a conserved DNA binding domain, the Runt domain (RD), named after the first member of this group – Runt - found in Drosophila melanogaster. LÄS MER

4. 3. Formation of Pebble-Pile Planetesimals and the Interior Structure of Comets

   Författare :Karl Wahlberg Jansson; Astronomi - Genomgår omorganisation; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; planets and satellites: formation; minor planets; asteroids: general; comets: general;

   Sammanfattning : Planets form in protoplanetary discs of gas, dust and ice around newborn stars. In the Solar System, not only planets are found as a result from the time of planet formation, but also remnant planetesimals in the form of asteroids, Kuiper belt objects and comets. Recent observations, e.g. LÄS MER

5. 4. On Cyber-Security for In-Vehicle Software

   Författare :Aljoscha Lautenbach; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Vehicular Security; Memory Protection; Automotive Security; Memory Exploitation; In-Vehicle Network; Risk Assessment; CAN authentication; Secure Software Development;

   Sammanfattning : We live in a highly connected world, which brings many opportunities, but which also makes us vulnerable to attacks. Security in regular IT systems, such as desktop and server systems, has decades of active research behind it, whereas security in the automotive domain is still a relatively new topic. LÄS MER

7. 5. Escherichia coli Fimbriae, Bacterial Persistence and Host Response Induction in the Human Urinary Tract

   Författare :Göran Bergsten; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; virology; bacteriology; Microbiology; IL-8; IL-6; neutrophils; GFP; mucosal host response; Type 1 fimbriae; P fimbriae; adherence; virulence factors; regulation; deliberate colonisation; Escherichia coli 83972; Urinary tract infection; asymptomatic bacteriuria;

   Sammanfattning : Urinary tract infections (UTI) are among the most common bacterial infections in humans. Symptomatic UTIs may be acute, recurrent or chronic but the most frequent form of UTI is asymptomatic bacteruria (ABU). In ABU, the mucosa remains inert, despite the presence of large bacterial numbers in urine. LÄS MER