Sökning: "C8-oxidation capillary elearophoresis dimethylxanthines high-performance liquidchromatography liver"

Hittade 1 avhandling innehållade orden C8-oxidation capillary elearophoresis dimethylxanthines high-performance liquidchromatography liver.

1. 1. Elimination of caffeine metabolites in man

   Författare :Nikolaos Rodopoulos; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :C8-oxidation capillary elearophoresis dimethylxanthines high-performance liquidchromatography liver cirrhosis N-acetylation N-demethylation monomethylurates monomethylxanthines;

   Sammanfattning : Plasma, saliva and urinary caffeine (CA), paraxanthine (PX), theobromine (TB), theophylline (TP) and their metabolites were, after separation into fractions by reversed-phase high-performance liquid chromatography (HPLC), quantitated by capillary electrophoresis (CE). In healthy adults, 96% of the total amount of excreted compounds derived from CA were dimethylxanthines (DMXs) and metabolites, the remainder 4% being nonmetabolized CA and its non-demethylated urate. LÄS MER