Sökning: "C4BP"

Visar resultat 6 - 10 av 27 avhandlingar innehållade ordet C4BP.

1. 6. Interactions of human C4BP with Bordetella pertussis and Streptococcus pyogenes

   Författare :Karin Berggård; Lund Dermatologi och venereologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; M protein; antigenic variation; phagocytosis resistance; complement; C4b-binding protein C4BP ; Bordetella pertussis; Streptococcus pyogenes; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

   Sammanfattning : Many microorganisms have developed mechanisms to protect themselves against attack from the complement system of the host. One possible mechanism for a microorganism to evade complement attack is to bind a human complement regulator, which may allow the microorganism to down-regulate complement activation. LÄS MER

3. 7. Innate immunity in diabetes mellitus. Complement components C4BP and C3 promote survival of β cells under metabolic challenges

   Författare :Klaudia Kulak; Malmö Proteinkemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement System; Inflammasome; Islet Amyloid Polypeptide; Complement C3; C4b-binding protein C4BP ; Interleukin 1β; Autophagy-Related Protein 16 like 1; Diabetes mellitus; type 2;

   Sammanfattning : The Complement system is a main effector mechanism of the innate immune system, acting to enhance clearance of pathogens, but also aids removal of biological debris from the body, including immunocomplexes, apoptotic/necrotic cells and protein aggregates. Complement regulators serve to prevent excessive inflammation and their interaction with the same materials targeted by the complement system results in ‘silent’ cleaning of wastes. LÄS MER

4. 8. C4b-binding protein: Identification of binding sites and a possible function of the interaction with protein S

   Författare :Joanna Webb; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; apoptosis; binding sites; complement; C4b-binding protein; protein S; Klinisk kemi;

   Sammanfattning : The subject of this thesis is plasma protein C4b-binding protein (C4BP). C4BP is an important regulator of the classical pathway of the complement system, a cascade-like system comprised of over 35 proteins, which partakes in the defence against micro-organisms and is involved of clearance of immune-complexes and apoptotic cells. LÄS MER

5. 9. Interactions between Streptococcus pyogenes and the human immune system, with special reference to C4b-binding protein

   Författare :Anette Thern; Avdelningen för medicinsk mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; Phagocytosis; M-proteins; M-like proteins; Bovine C4b-binding protein; Streptococcus pyogenes; Human C4b-binding protein; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

   Sammanfattning : The ability of many pathogenic microorganisms to cause infection is dependent on their ability to evade attack by the complement system of the host. One mechanism by which microorganisms may avoid complement attack is to bind complement inhibitory molecules present in the host. LÄS MER

7. 10. Studies on streptococcal M proteins. Interactions with IgA and human complement regulators

   Författare :Eskil Johnsson; Institutionen för laboratoriemedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; antigenic variation; factor H; C4b-binding protein; Fc-receptor; IgA; Streptococcus pyogenes; M protein; mykologi; virologi; bakteriologi; Mikrobiologi; virology; mycology; bacteriology;

   Sammanfattning : The human pathogenic bacterium Streptococcus pyogenes (group A Streptococcus) expresses several different virulence factors. Of these, the M protein is regarded as one of the most important, because it confers resistance to phagocytosis, allowing the bacterium to multiply in blood. LÄS MER