Sökning: "C3 complement"

Visar resultat 11 - 15 av 80 avhandlingar innehållade orden C3 complement.

  1. 11. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Författare :Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; Clinical immunology; Klinisk immunologi; Tumour immunology; Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  3. 12. Initiation of alternative pathway of complement, and development of novel liposomal coatings

    Författare :Anna Adler; Yuji Teramura; Penti Tengvall; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; complement system; C3; liposomes; polymer-lipids; Immunologi; Immunology;

    Sammanfattning : The complement system is a central part of the innate immune system, and is an essential part in recognizing and clearing non/altered-self surfaces in the body. This thesis comprises of projects in which the initiation of the alternative pathway (AP) of complement in the fluid phase as well on various artificial and lipid surfaces has been studied. LÄS MER

  4. 13. Modern roles for an ancient system. Intracellular Complement in the regulation of β cell function

    Författare :Ewelina Golec; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement system; Diabetes mellitus; Insulin secretion; CD59; C3; Isoforms; SNARE proteins;

    Sammanfattning : Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. LÄS MER

  5. 14. Interactions between platelets and complement with implications for the regulation at surfaces

    Författare :Per H. Nilsson; Kristina Nilsson Ekdahl; John Lambris; Ian Nicholls; Berhane Ghebrehiwet; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complement system activation; regulation ; platelets activation; regulation ; biomaterials; biocompatibility; chondroitin sulfate-A; apyrase; C1q; C3; factor H; C4BP; ADP; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Disturbances of host integrity have the potential to evoke activation of innate immunologic and hemostatic protection mechanisms in blood. Irrespective of whether the activating stimulus is typically immunogenic or thrombotic, it will generally affect both the complement system and platelets to a certain degree. LÄS MER

  7. 15. IgG3 Complements IgM in the Complement-Mediated Regulation of Immune Responses

    Författare :Lu Zhang; Birgitta Heyman; Jenny Hallgren; Frida Henningsson; Kristina Lejon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG3; IgM; marginal zone B cells; follicular dendritic cells; complement receptors 1 and 2; C1q; C3; antigen transport; Immunologi; Immunology;

    Sammanfattning : An intact complement system is essential for the initiation of a normal antibody response. Antibodies can regulate their own production against the antigens that they are specific for. Both IgG3 and IgM are able to enhance the antibody response via complement. LÄS MER