Sökning: "C2H2 Zinc-Finger"

Hittade 3 avhandlingar innehållade orden C2H2 Zinc-Finger.

  1. 1. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins

    Detta är en avhandling från Molecular Biophysics, Lund University

    Författare :Elmar Nurmemmedov; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; function; structure; transcription factor; cancer; affinity; kinetics; Biacore; RNA binding; DNA binding; Wilms tumour WT1 ; zinc finger;

    Sammanfattning : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. LÄS MER

  2. 2. Structural and Functional Studies of the Wilms' Tumour 1 Protein (WT1) in Interaction with Nucleic acids

    Detta är en avhandling från Molecular Biophysics, Lund University

    Författare :Raymond Yengo Kimbung; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; WT1; Zinc finger; Structure; Transcription factor;

    Sammanfattning : The WT1 protein, a product of the Wilms’ tumour 1 gene (WT1) is a zinc finger transcription factor implicated in a number of cellular processes particularly involved in the development of the urogenital system. Mutations in this gene have been implicated in abnormal development of the urogenital system resulting in syndromes such as the Denys-Drash, WAGR and Frasier and in the childhood kidney malignancy, Wilms’ tumour. LÄS MER

  3. 3. Probabilistic Modelling of Domain and Gene Evolution

    Detta är en avhandling från Molecular Biophysics, Lund University

    Författare :Sayyed Auwn Muhammad; Jens Lagergren; Bastien Boussau; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phylogenetics; Phylogenomics; Evolution; Domain Evolution; Gene tree; Domain tree; Bayesian Inference; Markov Chain Monte Carlo; Homology Inference; Gene families; C2H2 Zinc-Finger; Reelin Protein; Computer Science; Datalogi;

    Sammanfattning : Phylogenetic inference relies heavily on statistical models that have been extended and refined over the past years into complex hierarchical models to capture the intricacies of evolutionary processes. The wealth of information in the form of fully sequenced genomes has led to the development of methods that are used to reconstruct the gene and species evolutionary histories in greater and more accurate detail. LÄS MER