Sökning: "C2 domain"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden C2 domain.

  1. 11. Crystallographic studies of gluconate kinase

    Författare :Louise Kraft; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The first steps of gluconate metabolism in Escherichia coli are the transport of gluconate into the cell by a gluconate transport system, followed by phosphorylation to gluconate-6- phosphate by gluconate kinase. There exist two such different pathways, Grill and GntIl, respectively. LÄS MER

  3. 12. Medin Amyloid in Human Arteries and its Association with Arterial Diseases

    Författare :Siwei Peng; Per Wstermark; Gunnar Husby; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Amyloid; Medin; Lactadherin; Aneurysm; Aortic dissection; Temporal artery; Arteritis; Giant cell; Pre-aggregation.; Patologi; Pathology; Patologi;

    Sammanfattning : Amyloid is a form of abnormal protein aggregation within the living body. Massive deposits can lead to organ failure. There is also increasing evidence that smaller pre-amyloid aggregates exert direct toxic effects to cells. LÄS MER

  4. 13. β-alanine synthase : one reaction, two folds and mechanisms

    Författare :Stina Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : beta-alanine synthase (betaAS) is the third enzyme in the reductive pyrimidine catabolic pathway which is responsible for the breakdown of pyrimidine bases, including several anti-cancer drugs in higher organisms. We have solved the high resolution structures of two beta-alanine synthases that perform the same reaction but have two very different folds and utilize different reaction mechanisms. LÄS MER

  5. 14. Structural biology of carbohydrate transfer and modification in natural product biosynthesis

    Författare :Magnus Claesson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Certain organisms, can during periods of limited resources, adapt their metabolism to enable biosynthesis of secondary metabolites, compounds that increase competitiveness and chances of survival. The subjects of this thesis are enzymes acting on carbohydrate substrates during secondary metabolism. LÄS MER

  7. 15. Suppressor of zeste 12, a Polycomb group gene in Drosophila melanogaster; one piece in the epigenetic puzzle

    Författare :Anna Birve; Anssi Saura; Allen Shearn; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Drosophila melanogaster; epigenetic; homeotic genes; Polycomb group; PRE; heterochromatin; Suppressor of zeste 12; chromatin silencing; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

    Sammanfattning : In multicellular organisms all cells in one individual have an identical genotype, and yet their bodies consist of many and very different tissues and thus many different cell types. Somehow there must be a difference in how genes are interpreted. So, there must be signals that tell the genes when and where to be active and inactive, respectively. LÄS MER