Sökning: "C-terminal peptide"

Visar resultat 6 - 10 av 110 avhandlingar innehållade orden C-terminal peptide.

  1. 6. Molecular aspects of proinsulin C-peptide interactions

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medical Biochemistry and Biophysics

    Författare :Mikael Henriksson; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes mellitus; proinsulin C-peptide;

    Sammanfattning : Insulin biosynthesis in the beta-cells of the pancreas begins with the generation of preproinsulin, which is converted to proinsulin. Proinsulin is cleaved into equimolar amounts of insulin and connecting peptide (Cpeptide), which are released into the circulation. LÄS MER

  2. 7. Proinsulin C-peptide : Membrane interactions and intracellular signaling

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Surgical Science

    Författare :Zhihui Zhong; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human renal tubular cell; intracellular signal transduction; ERK1 2; JNK; Na ; K -A TPase; G-protein coupled receptor.;

    Sammanfattning : In the past decade, new evidence has emerged of a physiological role for C-peptide. C-peptide replacement improves renal and nerve function and augments regional blood flow in type I diabetic patients. LÄS MER

  3. 8. Mass spectrometry in peptide and tumor marker analysis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medical Biochemistry and Biophysics

    Författare :Ann-Charlotte Bergman; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Integration of preparative protein and peptide separations with analytical techniques, in particular mass spectrometry (MS), is important. This thesis describes preparation via capillary electrophoresis and two-dimensional (2-D) gel electrophoresis for identification and structure determination of polypeptides. LÄS MER

  4. 9. The effect of galanin message-associated peptide in spinal sensory processing

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Siv Andell-Jonsson; Karolinska Institutet.; Karolinska Institutet.; [1997]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galanin; galanin message-associated peptide; spinal cord; flexor reflex; nociception;

    Sammanfattning : The effect of Galanin Message-Associated Peptide in spinal sensoryprocessing Galanin message associated peptide (GMAP), the C-terminal flanking peptide inthe precursor protein of galanin, has been studied to established whether this peptidehas its own biological action. With some exceptions, GMAP is generally colocalizedwith galanin in the central nervous system as well as the peripheral nervous system. LÄS MER

  5. 10. C-peptide structural and functional relationships studied by biosensor technology and mass spectrometry

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medical Biochemistry and Biophysics

    Författare :Ermias Melles; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proinsulin C-peptide; biosensor; mass spectrometry;

    Sammanfattning : Proinsulin C-peptide has a number of biological activities and receives interest focusing on the therapeutic potential as a candidate for future co-replacement therapy with insulin in type 1 diabetes. Based on conservation results from comparisons of 22 mammalian proinsulin variants, analogs were constructed for studies of phosphorylation of mitogenactivated protein kinases (MAPKs) in Swiss 3T3 fibroblasts. LÄS MER