Sökning: "C-terminal peptide"

Visar resultat 1 - 5 av 112 avhandlingar innehållade orden C-terminal peptide.

  1. 1. Hydrophobic interactions of serpins

    Detta är en avhandling från Sabina Janciauskiene, Wallenberglab, University Hospital Malmö, S-20502 Malmö, Sweden

    Författare :Sabina Janciauskiene; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteiner; enzymology; polymerization.; Proteins; conformational polymorphism; hydrophobic interaction; amyloid fibrils; Alzheimer`s peptide Ab; alpha-1-antichymotrypsin; C-terminal peptide; lithocholic acid; cholesterol; Key words: alpha-1-antitrypsin; bile acids; enzymologi;

    Sammanfattning : The proteins of the serpin family are primarily but not exclusively proteinase inhibitors, which share a common, similar structure. It is known that this structure undergoes major conformational changes upon cleavage in the serpin reactive site loop, and that these changes include rearrangements within the hydrophobic core of the molecule. LÄS MER

  2. 2. Using peptide-phage display to capture conditional motif-based interactions

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Gustav Sundell; Ylva Ivarsson; Per Jemth; Attila Reményi; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interaction; PDZ domain; phosphorylation; peptide-phage display; ProP-PD; phospho-peptide; phosphomimetic substitution; Scribble; NMR; DLG1; PTM; affiinity; Biokemi; Biochemistry;

    Sammanfattning : This thesis explores the world of conditional protein-protein interactions using combinatorial peptide-phage display and proteomic peptide-phage display (ProP-PD). Large parts of proteins in the human proteome do not fold in to well-defined structures instead they are intrinsically disordered. LÄS MER

  3. 3. Conformational Studies of Biologically Active Peptides

    Detta är en avhandling från Physical Chemistry 2, Lund University

    Författare :Björn Walse; [1997]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PapD chaperone; P pili; desmopressin; DDAVP; protein-peptide interactions; glycopeptides; peptide design; transferred NOE; molecular dynamics simulations; circular dichroism; peptide conformation; NMR spectroscopy; immunogenic glycopeptides; Physical chemistry; Fysikalisk kemi;

    Sammanfattning : In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. LÄS MER

  4. 4. NMR studies of the amyloid beta-peptide

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Jens Danielsson; Astrid Gräslund; Chris Dobson; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR; amyloid beta peptide; structure; metal interaction; diffusion; TECHNOLOGY Engineering physics Biophysics; TEKNIKVETENSKAP Teknisk fysik Biofysik;

    Sammanfattning : The Amyloid beta peptide (Ab) is related to Alzheimer’s disease and is suggested to be the molecular pathogenic species of the disease, probably through the neurotoxic effect of Ab oligomers. Here the results from biophysical studies of Ab and fragments thereof, are presented. LÄS MER

  5. 5. Substrate specificity of protein kinases studied with synthetic peptides

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Reet Toomik; [1997]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; protein kinase A; protein kinase C; substrate; peptide; specificity; stereospecificity; assay; SPOTS peptides; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : This thesis concentrates on the substrate specificities of protein kinases A and C (PKA, PKC). Synthetic peptides are used for that purpose, both in soluble and cellulose membrane-bound form. The, stereospecificity of both protein kinases was studied with D-amino acid containing synthetic peptides. LÄS MER