Sökning: "C Edlund"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden C Edlund.

1. 1. A study of the cytoplasmic domains of C-CAM isoforms : calmodulin binding and phosphorylation

   Författare :Magnus Edlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :adhesion molecules; adhesion regulation; BGP; Bgp; biliary glycoprotein; Calcium; Calmodulin; CaM; CAMs; carcinoembryonic antigen gene family; C-CAM; CEA; cell adhesion; Immunoglobulin super-family; PKC; protein kinase C.;

   Sammanfattning : C-CAM, a member of the Immunoglobulin Superfamily, was originally identified as an intercellular adhesion molecule, and can mediate cell-cell adhesion by homophilic binding. However, it also appears in high concentrations in luminal, microvillar surfaces. LÄS MER

3. 2. Oxygen sensing in Caenorhabditis elegans

   Författare :Lina Zhao; Changchun Chen; Simon Tuck; Helena Edlund; Marc Pilon; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; C. elegans; acute hypoxia; G-protein; mitochondrial ROS; neuropeptide; GPCR;

   Sammanfattning : Sufficient supply of oxygen (O2) to tissue is essential for survival of aerobicanimals. In mammals, there are constant homeostatic regulation mechanisms that act on different time scales to maintain optimal O2 delivery to tissues. The ability to detect and respond to acute oxygen shortages is indispensable to aerobic life. LÄS MER

4. 3. On Vertex Operator Algebras of Affine Type at Admissible Levels

   Författare :Thomas Edlund; Matematik (naturvetenskapliga fakulteten); []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Vertex operator algebras; Kac-Moody algebras; Ore localization; Admissible levels; Singular vectors; Intertwining operators;

   Sammanfattning : The main purpose of this thesis is the study of the structure and representation theory of simple vertex operator algebras (VOAs) of affine type at admissible levels. To do this, it is crucial to obtain knowledge of the singular vectors which generate the maximal submodules, with respect to which these VOAs appear as irreducible quotients, and therefore a substantial part of the text is devoted to this matter. LÄS MER

5. 4. CFTR in pancreatic islets

   Författare :Anna Edlund; Diabetes - öcellsexocytos; []
   Nyckelord :CFTR; CF; CFRD; Cystic fibrosis; Cystisk fibros; Diabetes; Insulin; Beta cell; Glukagon; Glucagon; Alpha cell; Alfa-cell; Anoctamin; ANO1; ANO;

   Sammanfattning : AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. LÄS MER

7. 5. Mechanisms for TGF-β-Mediated Regulation of the Actin Filament System and Apoptosis

   Författare :Sofia Edlund; Pontus Aspenström; Maréne Landström; Tommy Andersson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-beta; cytoskeleton; GTPases; mitogen-activated protein kinase kinase 3; TGF-beta-activated kinase 1; Apoptosis; Smad7; beta-catenin; p38 MAPK; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Transforming growth factor-β (TGF-β) is a member of a large superfamily of cytokines which participate in many different types of cellular processes, such as growth inhibition, cell migration, differentiation, cell adhesion, wound healing and immunosuppression. Alterations of TGF-β superfamily signalling results in several different disorders, including bone disease, vascular disease and cancer. LÄS MER