Sökning: "Broca"

Hittade 5 avhandlingar innehållade ordet Broca.

  1. 1. Mind your Language, All Right? Performance-dependent neural patterns of language

    Författare :Helene van Ettinger-Veenstra; Maria Engström; Peter Lundberg; Thomas Karlsson; Anita McAllister; Karsten Specht; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Language ability; performance; fMRI; functional magnetic resonance imaging; Broca; Wernicke; temporal lobe; inferior frontal gyrus; reading; fluency; lateralization; lateralisation; right hemisphere; performance-dependent; neural activation;

    Sammanfattning : The main aim of this dissertation was to investigate the difference in neural language patternsrelated to language ability in healthy adults. The focus lies on unraveling the contributions of theright‐hemispheric homologues to Broca’s area in the inferior frontal gyrus (IFG) and Wernicke’s areain the posterior temporal and inferior parietal lobes. LÄS MER

  3. 2. Cholinergic and dopaminergic aspects of dementia in Parkinson's disease: postmortem neuropathological findings and modeling of cognitive dysfunction in rodents

    Författare :Helene Hall; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-synuclein; animal model; choline acetyltransferase; cholinergic neurons; cognition; dementia; dopaminergic neurons; Lewy bodies; Parkinson s disease; magnetic resonance spectroscopy;

    Sammanfattning : Motor symptoms are currently considered the first clinical hallmark of Parkinson’s disease (PD). They develop as a result of dopamine loss in the striatum, subsequent to the progressive neurodegeneration of dopamin- ergic neurons in the substantia nigra. LÄS MER

  4. 3. Serotonergic receptor subtypes in learning and memory : focus on 5-HT1A, 5-HT1B and 5-HT2A receptors

    Författare :Maria Lüttgen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Serotonin; 5-HT1A receptor; 5-HT1B receptor; 5-HT2A receptor; acetylcholine; NMDA receptor; water maze; passive avoidance; septum; hippocampus; teaming; memory; immunohistochemistry; mRNA;

    Sammanfattning : The aim of this thesis was to study how serotonin (5-HT) receptor subtypes can influence hippocampus/amygdala-dependent teaming and memory using the water maze (WM) and the passive avoidance (PA) tasks in rodents, and to provide a cellular correlate to the behavioral results using histochemical methods. Glutamatergic neurons in the trisynaptic circuit of the hippocampus are believed to be important for spatial teaming and memory as well as synaptic plasticity. LÄS MER

  5. 4. Neurochemical regulators of the septohippocampal pathway : role in spatial and aversive learning

    Författare :Elin Elvander Tottie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetylcholine; muscarinic receptor; galanin; serotonin; 5-HT1A receptor; glutamate; NMDA receptor; water maze; passive avoidance; septum; hippocampus; learning; memory; spatial; aversive; emotional; cognition;

    Sammanfattning : The aim of this thesis was to investigate the significance of major neurotransmitters in the septohippocampal pathway for hippocampal-dependent learning and memory. The cholinergic and GABAergic neurons in the medial septal/vertical limb of the diagonal band of Broca area (MS/vDB) projecting to the hippocampus, constitute the septohippocampal pathway, which has been implicated in a number of important functions such as attention, anxietylike behavior and hippocampal-dependent learning and memory. LÄS MER

  7. 5. Modeling disturbances of cholinergic systems : possible relevance for schizophrenia

    Författare :Anna Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholinergic; nucleus basalis; 192 IgG-saporin; schizophrenia; locomotor activity; dopamine; microdialysis; memory; MRI;

    Sammanfattning : Schizophrenia is a severe, chronic mental disorder. The etiology remains unknown but alterations in cholinergic neurotransmission is one, among other, disturbances in the brain that have been implicated in schizophrenia. LÄS MER