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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Chromatin Remodeling by BRG1 and SNF2H : Biochemistry and Function

    Författare :Patrik Asp; Ann-Kristin Östlund Farrants; Anthony Imbalzano; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chromatin; chromatin remodeling; SWI SNF; ISWI; BRG1; SNF2H; Prp8; RNA; transcription; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Chromatin is a highly dynamic, regulatory component in the process of transcription, repair, recombination and replication. The BRG1 and SNF2H proteins are ATP-dependent chromatin remodeling proteins that modulate chromatin structure to regulate DNA accessibility for DNA-binding proteins involved in these processes. LÄS MER

  3. 2. Gene regulation by chromatin remodelling complexes : SWI/SNF complex in mRNA processing and B-WICH complex in ribosomal gene expression

    Författare :Antoni Gañez Zapater; Ann-Kristin Östlund-Farrants; Christopher W.J. Smith; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromatin remodelling; SWI SNF; Brg1; Brm; alternative splicing; cleavage and polyadenylation; B-WICH; WSTF; ribosomal genes; Cell Biology; cellbiologi;

    Sammanfattning : The aim of this project is to investigate the roles of chromatin remodelling complexes in gene regulation. It is focused on two groups of chromatin complexes: the mammalian BRG1 and BRM SWI/SNF complexes and the ISWI-containing B-WICH complex.Study 1 investigates the role of SWI/SNF complexes in alternative splicing. LÄS MER

  4. 3. Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation

    Författare :Dzeneta Vizlin-Hodzic; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; Oct4; SAF-A; Brg1; Tpt1; Npm1; transcriptional regulation; cell proliferation; shelterin;

    Sammanfattning : Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene expression, high telomerase activity and specific cell proliferation, characteristics shared with cancer stem cells. LÄS MER

  5. 4. Chromatin remodelling and gene regulation

    Författare :Birgitta Gelius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and some of these are important for gene regulation. LÄS MER

  7. 5. The secret life of nuclear IGF-1R : functions beyond traditional signaling pathways

    Författare :Dudi Warsito; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The implications of IGF-1R in normal development and disease are well established. IGF-1R plays pivotal roles in cell proliferation and cell survival and aberrant activation result in tumorigenesis and cancer progression. LÄS MER