Sökning: "Breast tumor detection"

Visar resultat 21 - 25 av 46 avhandlingar innehållade orden Breast tumor detection.

  1. 21. Predictors of Lymph Node Metastasis in Primary Breast Cancer - Risk Models for Tailored Axillary Management

    Författare :Looket Dihge; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Axillary lymph node dissection; Sentinel lymph node biopsy; Ultrasonography; Nomogram; Artificial neural network; Gene Expression; Prediction model;

    Sammanfattning : Most patients with breast cancer present with low-risk tumors, node-negative disease, and excellent prognosis. For these patients, routine axillary nodal staging by sentinel lymph node biopsy (SLNB) has no therapeutic benefit. For patients with limited sentinel lymph node metastasis, completion axillary nodal dissection is controversial. LÄS MER

  3. 22. Genetic factors, body constitution, and tumor characteristics in relation to breast cancer prognosis

    Författare :Andrea Markkula; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Prior advancements in research on biomarkers and prognostic host factors have made it increasingly clear that breast cancer is an immensely heterogeneous disease. It remains difficult to predict which patients will benefit from different breast cancer treatments. Hence, interest in personalized medicine is internationally wide-spread and growing. LÄS MER

  4. 23. Molecular markers reflecting malignant transformation and tumor progression

    Författare :Patricia Stoltzfus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Molecular markers; interphase fluorescence in situ hytidization; genetic diagnostic test; laminin-5 gamma2 chain; immunohistochemistry; precancerous lesions; invasiveness; breast cancer; cervical squamous cell carcinoma; tongue carcinoma; vulvar carcinoma;

    Sammanfattning : The early detection of neoplastic lesions is most critical in the successful treatment of malignant disease. This thesis investigates molecular targets for an improved detection and diagnosis of cancer by exploring the value of interphase fluorescence in situ hybridization (FISH) to detect specific chromosomal aneuploidies and gene amplifications, and laminin-5 gamma2 chain expression detected by immunohistochemistry as a marker for invasiveness. LÄS MER

  5. 24. Integrative genomic and survival analysis of breast tumors

    Författare :Szilard Nemes; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biostatistics; cancer; survival analysis; gemonics; DNA copy number aberrations; messenger RNA;

    Sammanfattning : With the continued accumulation of genomic data at ever increasing resolution the challenge ahead lies in reading out meaningful clinical/biological information form the data that can contribute to a better understanding of the cancerous process. The need for novel approaches, new statistical methods is therefore strong. LÄS MER

  7. 25. Receptor tyrosine kinases and circulating tumor cells as new prognostic biomarkers in breast cancer with special focus on TNBC

    Författare :Sara Jansson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bröstcancer;

    Sammanfattning : About 8000 Swedish women are diagnosed with breast cancer each year, and around 1500 die from the disease. Triple-negative breast cancer (TNBC) constitutes 7-14% of all breast cancer and is characterized by an aggressive phenotype with poor prognosis and no targeted therapy available. LÄS MER